2411786-32-6
Chemical Structure
KRAS inhibitor-20
- CAS No.: 2411786-32-6
- Formula:C31H40F4N6O2
- Molecular Weight:604.68
IUPAC Name: 1-((S)-4-((6R,7R)-7-(3-amino-2-fluoro-5-methyl-6-(trifluoromethyl)phenyl)-6-methyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydroquinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one
InChIKey: NRFWNEBUKRLYDL-BVOGOJNSSA-N
SMILES: C[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=C(F)C(N)=CC(C)=C5C(F)(F)F)C4
Biological Activity: KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM[1].
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KRAS inhibitor-20 | KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM. | |||||||||||||||||||||
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Keywords
