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MEK/RAF-IN-1

MEK/RAF-IN-1 (Compound 16b) is an inhibitor of both MEK and RAF. It shows potent inhibition with IC50 values of 28 nM for MEK1, and 3 nM each for BRAF and BRAFV600E. MEK/RAF-IN-1 demonstrates significant antitumor activity, effectively inhibiting cell proliferation in vitro against MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Additionally, it inhibits tumor growth in xenograft mouse models of colorectal cancer.

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  • 分子式: C28H29F3N6O5S
  • 分子量:618.63
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • MEK/RAF-IN-1 Chemical Structure
    MEK/RAF-IN-1 構造式
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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  • MEK/RAF-IN-1 Chemical Structure
    MEK/RAF-IN-1 Chemical Structure
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  • MEK/RAF-IN-1