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MEK/RAF-IN-1

MEK/RAF-IN-1 (Compound 16b) is an inhibitor of both MEK and RAF. It shows potent inhibition with IC50 values of 28 nM for MEK1, and 3 nM each for BRAF and BRAFV600E. MEK/RAF-IN-1 demonstrates significant antitumor activity, effectively inhibiting cell proliferation in vitro against MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Additionally, it inhibits tumor growth in xenograft mouse models of colorectal cancer.

For research use only. We do not sell to patients.

  • Formula: C28H29F3N6O5S
  • Molecular Weight:618.63
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • MEK/RAF-IN-1 Chemical Structure
    MEK/RAF-IN-1 Chemical Structure
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Use of MCE Products

All MEK Isoforms

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All Raf Isoforms

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100 mg

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  • MEK/RAF-IN-1 Chemical Structure
    MEK/RAF-IN-1 Chemical Structure
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  • MEK/RAF-IN-1