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Cat. No.: HY-12446

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K-Ras(G12C) inhibitor 9

K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C).

For research use only. We do not sell to patients.

CAS No.: 1469337-91-4
Formula: C₁₆H₂₁ClIN₃O₄S
Molecular Weight:513.78

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

K-Ras(G12C) inhibitor 9 Chemical Structure

CAS No.: 1469337-91-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C)^[1].

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.2 μM Compound: SH-9	Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
MRC5	IC₅₀	10.3 μM Compound: SH-9	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H2228	IC₅₀	7.2 μM Compound: SH-9	Antiproliferative activity against human NCI-H2228 cells harboring wild type KRAS assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H2228 cells harboring wild type KRAS assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H23	IC₅₀	3 μM Compound: SH-9	Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H358	IC₅₀	4.4 μM Compound: SH-9	Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
NCI-H441	IC₅₀	21.5 μM Compound: SH-9	Antiproliferative activity against human NCI-H441 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H441 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]
SK-LU-1	IC₅₀	22.8 μM Compound: SH-9	Antiproliferative activity against human SK-LU-1 cells harboring KRAS G12D mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-LU-1 cells harboring KRAS G12D mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36228411]

Chemical Information

CAS No. 1469337-91-4
Appearance Solid
Molecular Weight 513.78
Formula C₁₆H₂₁ClIN₃O₄S
Color White to off-white
SMILES

C=CS(=O)(NC1CCN(C(CNC2=CC(I)=C(Cl)C=C2OC)=O)CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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Purity & Documentation
References

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K-Ras(G12C) inhibitor 9

High-Throughput Bioactive Compound Library

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

K-Ras(G12C) inhibitor 9 Related Classifications

HY-12446 Related Classifications