1. GPCR/G Protein MAPK/ERK Pathway Apoptosis
  2. Ras Apoptosis
  3. CCG-1423

CCG-1423 

Cat. No.: HY-13991 Purity: 99.94%
COA Handling Instructions

CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes.

For research use only. We do not sell to patients.

CCG-1423 Chemical Structure

CCG-1423 Chemical Structure

CAS No. : 285986-88-1

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 73 In-stock
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Solid
5 mg USD 42 In-stock
10 mg USD 66 In-stock
50 mg USD 211 In-stock
100 mg USD 370 In-stock
200 mg USD 594 In-stock
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of CCG-1423:

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Description

CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes[1][2][3].

IC50 & Target

IC50: 1.5 µM (Rho-pathway selective serum response element-luciferase reporter)[1]

In Vitro

CCG-1423 (10 μM; 24 h) affects invasion by cultured PC-3 cells into a Matrigel matrix and inhibits 54% mitochondrial metabolism of WST-1[1].
? CCG-1423 (0-100 μM; 24 h) inhibits RhoA and RhoC signaling pathways with an IC50 value of 1.5 μM for Rho-pathway selective serum response element-luciferase reporter[1].
? CCG-1423 (1 μM; 16 h) improves glucose uptake in both L6 cells and primary human myotubes[2].
? CCG-1423 (10 μM; 18-19 h) inhibits expression of Rho downstream[2].
? CCG-1423 (3 μM; 25 h) selectively stimulates apoptosis of RhoC-overexpressing melanoma cell line (A375M2) compared with the parental cell line (A375)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay[1]

Cell Line: PC-3 cell line
Concentration: 10 µM
Incubation Time: 24 hours
Result: Inhibited 71% invasion by cultured PC-3 cells into a Matrigel matrix.

Western Blot Analysis[2]

Cell Line: L6 myotubes
Concentration: 1 µM
Incubation Time: 48 hours
Result: Increased insulin-stimulated Akt phosphorylation, blocked ERK phosphorylation, and increased IRS-1 tyrosine phosphorylation and its association with the p85 regulatory subunit of PI3K.

Cell Proliferation Assay[3]

Cell Line: PC-3 cell line
Concentration: 0.3 µM
Incubation Time: 8 days
Result: Inhibited growth of PC-3 prostate cancer cells with an IC50 value of 1 µM with 30 µM LPA adding.

Apoptosis Analysis[3]

Cell Line: RhoC-overexpressing A375M2 and low RhoC-expressing A375 melanoma cell lines
Concentration: 3 µM
Incubation Time: 25 hours
Result: Stimulated apoptosis of A375M2 cell line compared with the parental cell line.
In Vivo

CCG-1423 (0.15 mg/kg; i.p. once daily for two weeks) affects glucose tolerance and insulin levels in HFD-fed mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 16-week-old mice with HFD-induced obesity[1]
Dosage: 0.15 mg/kg
Administration: Intraperitoneal injection; 0.15 mg/kg once per day; for two weeks
Result: Improved glucose tolerance and reduced insulin levels at 30 minutes after glucose injection.
Molecular Weight

454.75

Formula

C18H13ClF6N2O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NOC(C)C(NC1=CC=C(Cl)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.90 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1990 mL 10.9951 mL 21.9901 mL
5 mM 0.4398 mL 2.1990 mL 4.3980 mL
10 mM 0.2199 mL 1.0995 mL 2.1990 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

References
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CCG-1423 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CCG-1423
Cat. No.:
HY-13991
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