country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182749

Copy Link Print Information

KRAS-IN-58

KRAS-IN-58 is a KRAS inhibitor with a IC₅₀ of 0.223 μM against KRAS^G12D. KRAS-IN-58 binds to KRAS^G12C and KRAS^G12D proteins, and reduces the levels of phosphorylated Raf1, AKT and ERK in pancreatic cancer cells. KRAS-IN-58 can be used for the research of pancreatic cancer.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₇N₅O₃S₂
Molecular Weight:451.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-58 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

KRas G12D

223 nM (IC₅₀)

All Ras Isoforms :

All Akt Isoforms :

All Raf Isoforms :

All ERK Isoforms :

In Vitro

KRAS-IN-58 (Compound 10b) (24 h) inhibits viability of ASPC-1, PANC-1, and Miapac-2 pancreatic cancer cells with IC₅₀ values of 1.16 μM, 6.59 μM, and 6.432 μM, respectively^[1].
KRAS-IN-58 (24 h) inhibits viability of SW1990 pancreatic cancer cells with an IC₅₀ of 1.518 μM, while showing much weaker activity against LO2 normal hepatic cells (IC₅₀ = 55.53 μM) and HPDE6-C7 normal pancreatic epithelial cells (IC₅₀ = 10.50 μM), demonstrating selective activity for cancerous over non-cancerous cells^[1].
pan-KRAS-IN-19 (1.25-20 μM) dose-dependently downregulates levels of KRAS, pRaf1, pAKT, and pERK in ASPC-1 and Miapac-2 pancreatic cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	MRT	CL	V_ss	V_z	AUC
Mice^[1]	2 mg/kg	i.v.	4.3 h	/	/	0.512 h	66 mL/min/kg	2.6 L/kg	26 L/kg	510 ng·h/mL
Mice^[1]	10 mg/kg	p.o.	6.52 h	0.333 h	1.4 ng/mL	2.82 h	/	/	/	/

Chemical Information

Molecular Weight 451.52
Formula C₂₁H₁₇N₅O₃S₂
SMILES

CN1C=CC=C1/C=C2SC(N(C\2=O)CCSC3=NN=C(O3)C4=CNC5=C4C=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang P, et al. Active fragment assembly strategy enabling fast discovery of KRAS inhibitors against pancreatic cancer cells. Eur J Med Chem. 2026;310:118807. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

KRAS-IN-58

All Ras Isoforms

All Akt Isoforms

All Raf Isoforms

All ERK Isoforms