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Art. -Nr.: HY-182749

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KRAS-IN-58

KRAS-IN-58 is a KRAS inhibitor with a IC₅₀ of 0.223 μM against KRAS^G12D. KRAS-IN-58 binds to KRAS^G12C and KRAS^G12D proteins, and reduces the levels of phosphorylated Raf1, AKT and ERK in pancreatic cancer cells. KRAS-IN-58 can be used for the research of pancreatic cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₁H₁₇N₅O₃S₂
Molecular Weight:451.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-58 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

KRas G12D

223 nM (IC₅₀)

Alle Ras Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle Raf Isoform-spezifische Produkte anzeigen :

Alle ERK Isoform-spezifische Produkte anzeigen :

In Vitro

KRAS-IN-58 (Compound 10b) (24 h) inhibits viability of ASPC-1, PANC-1, and Miapac-2 pancreatic cancer cells with IC₅₀ values of 1.16 μM, 6.59 μM, and 6.432 μM, respectively^[1].
KRAS-IN-58 (24 h) inhibits viability of SW1990 pancreatic cancer cells with an IC₅₀ of 1.518 μM, while showing much weaker activity against LO2 normal hepatic cells (IC₅₀ = 55.53 μM) and HPDE6-C7 normal pancreatic epithelial cells (IC₅₀ = 10.50 μM), demonstrating selective activity for cancerous over non-cancerous cells^[1].
pan-KRAS-IN-19 (1.25-20 μM) dose-dependently downregulates levels of KRAS, pRaf1, pAKT, and pERK in ASPC-1 and Miapac-2 pancreatic cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	MRT	CL	V_ss	V_z	AUC
Mice^[1]	2 mg/kg	i.v.	4.3 h	/	/	0.512 h	66 mL/min/kg	2.6 L/kg	26 L/kg	510 ng·h/mL
Mice^[1]	10 mg/kg	p.o.	6.52 h	0.333 h	1.4 ng/mL	2.82 h	/	/	/	/

Chemical Information

Molecular Weight 451.52
Formel C₂₁H₁₇N₅O₃S₂
SMILES

CN1C=CC=C1/C=C2SC(N(C\2=O)CCSC3=NN=C(O3)C4=CNC5=C4C=CC=C5)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhang P, et al. Active fragment assembly strategy enabling fast discovery of KRAS inhibitors against pancreatic cancer cells. Eur J Med Chem. 2026;310:118807. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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KRAS-IN-58

Alle Ras Isoform-spezifische Produkte anzeigen

Alle Akt Isoform-spezifische Produkte anzeigen

Alle Raf Isoform-spezifische Produkte anzeigen

Alle ERK Isoform-spezifische Produkte anzeigen