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Results for "

SW1990

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

4

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135770
    9-Dehydroxyeurotinone

    		Others Cancer
    9-Dehydroxyeurotinone is an anthraquinone derivative that can be found in Eurotium rubrum. 9-Dehydroxyeurotinone shows cytotoxicity with an IC50 value of 25 µg/mL for SW1990 cells .
    9-Dehydroxyeurotinone
  • HY-N12147
    Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside

    		Others Cancer
    Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside (Compound 12) is a cardiac glycoside that can be isolated from seeds of Thevetia peruvian. Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside shows cytotoxicity against SW1990 and MGC-803 cells (IC50: 9.52 and 7.70 μM) .
    Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside
  • HY-155303
    DCLK1-IN-2

    		Ser/Thr Protease Cancer
    DCLK1-IN-2 (compound I-5) is a potent DCLK1 inhibitor with an IC50 of 171.3  nM. DCLK1-IN-2 shows remarkable antiproliferative effects on SW1990 cell lines (IC50 of 0.6 μM) and in vivo antitumor potency .
    DCLK1-IN-2
  • HY-146094
    Antitumor agent-63

    		Topoisomerase Cancer
    Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition .
    Antitumor agent-63
  • HY-N10588
    Nardoguaianone K

    10-epi-Nardoguaianone J

    		 Others Cancer
    Nardoguaianone K, a guaiane-type compound, can be isolated from Nardostachys chinensis roots. Nardoguaianone K cam be used in the research of pancreatic cancer .
    Nardoguaianone K
  • HY-158008
    (R)-G12Di-7

    		Ras Cancer
    (R)-G12Di-7 is a covalent ligand for KRAS-G12D, which selectively labels K-Ras-G12D·GDP and K-Ras-G12D·GppNHp. (R)-G12Di-7 exhibits inhibitory activity against G12D mutated cancer cells .
    (R)-G12Di-7
  • HY-144661
    KRAS G12D inhibitor 14

    		Ras Apoptosis Cancer
    KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D .
    KRAS G12D inhibitor 14
  • HY-111934
    Cymarin

    		Others Parasite Others Cancer
    Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K + release (IC50=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer . Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .
    Cymarin
  • HY-144338
    PARP1/BRD4-IN-1

    		Epigenetic Reader Domain PARP Apoptosis DNA/RNA Synthesis Cancer
    PARP1/BRD4-IN-1 is a potent and high selective PARP1/BRD4 inhibitor (IC50s of 49 and 202 nM in PARP1 and BRD4, respectively). PARP1/BRD4-IN-1 represses the expression and activity of PARP1 and BRD4 to synergistically inhibit the malignant growth of pancreatic cancer cells .
    PARP1/BRD4-IN-1

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