Cat. No.: HY-111934

Cymarin

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Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant.

For research use only. We do not sell to patients.

Purity: 97.28%
CAS No.: 508-77-0
Formula: C₃₀H₄₄O₉
Molecular Weight:548.66

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cymarin Chemical Structure

CAS No.: 508-77-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	39 nM Compound: Cymarin	Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program	[PMID: 15743190]

In Vitro

Cymarin (0.25-1 μM) inhibites PAX6 expression by blocking IRES-directed translation and inhibits 47.8% proliferation of MCF-7 cells with the concentration of 1 μM ^[2].
Cymarin downregulates UGT1A10 expression, eliminates TRA-1-60 (IC₅₀ of 15.2 nM) and TRA-1-81 cells (IC₅₀ of 5.1 nM) in cell lines SW1990GR, inhibits proliferations and cell viabilities of pancreatic cancer cells SW1990 and SW1990GR (IC₅₀ of 33.8 nM for SW1990 and 40.8 nM for SW1990GR)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:

SW1990 and SW1990GR
Concentration:

0-500 nM
Incubation Time:

72 h
Result:

Decreased cell viability with IC₅₀ of 33.8 nM for SW1990 and 40.8 for SW1990GR.

Cell Proliferation Assay^[2]

Cell Line:

MCF-7
Concentration:

0.25-1 μM
Incubation Time:

5 days
Result:

Inhibits proliferation of MCF-7 cells in a dose-dependent manner.

Western Blot Analysis^[2]

Cell Line:

MCF-7
Concentration:

0.25-1 μM
Incubation Time:

24 h
Result:

Downregulated levels of PAX6.

Real Time qPCR^[4]

Cell Line:

SW1990 and SW1990GR
Concentration:

7-15 μM
Incubation Time:
Result:

Decreased levels of UGT1A10 transcription.

In Vivo

Cymarin inhibits growth of neonate Trichoplusia ni larvae with EC₅₀ of 157 p.p.m, reveals an antifeedant effect against Trichoplusia ni larva with a DC₅₀ of 10.8 μg/cm²^[3].
Cymarin (2 mg/kg, i.p., twice a week for 3 weeks) inhibits tumor growth, eliminates TRA-1-60 cells and decreases chemoresistance in SW1990 xenografted nude mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Trichoplusia ni^[3]
Dosage:

1000 p.p.m.
Administration:

p.o. for 10 days
Result:

Inhibited growth and revealed a feeding deterrent to T.ni.

Animal Model:

Luciferase labeled SW1990 xenograft in nude mice^[4]
Dosage:

2 mg/kg
Administration:

i.p., twice a week for 3 weeks
Result:

Inhibited tumor growth.

Chemical Information

CAS No. 508-77-0
Appearance Solid
Molecular Weight 548.66
Formula C₃₀H₄₄O₉
Color White to off-white
SMILES

O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O[C@@]4([H])C[C@@H]([C@H](O)[C@@H](C)O4)OC)CC2)O)([H])[C@@]5([C@@](C)([C@@H](C(CO6)=CC6=O)CC5)CC3)O
Structure Classification
- Steroids
- Cardiacglycosides
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152(2):475-480. [Content Brief]

[2]. Li Q, et al., Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes Genet Syst. 2023 Oct 24;98(4):161-169. [Content Brief]

[3]. Akhtar Y, et al., Comparative growth inhibitory and antifeedant effects of plant extracts and pure allelochemicals on four phytophagous insect species. J Applied Entomology. 10 February 2004.128,32-38.

[4]. Tan L, et al., A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. J Mol Cell Biol. 2023 Nov 27;15(6):mjad039. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cymarin

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Cymarin

Anti-Infection Compound Library

Membrane Transporter/Ion Channel Compound Library

Natural Product Library

Anti-Cancer Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Alzheimer's Disease Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Antiparasitic Compound library

Neurodegenerative Disease-related Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Potassium Channel Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cymarin Related Classifications

HY-111934 Related Classifications