Cymarin 

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K⁺ release (IC₅₀=0.42 μM)^[1]. Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer^[2][4]. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant^[3].

Cymarin (0.25-1 μM) inhibites PAX6 expression by blocking IRES-directed translation and inhibits 47.8% proliferation of MCF-7 cells with the concentration of 1 μM ^[2].
Cymarin downregulates UGT1A10 expression, eliminates TRA-1-60 (IC₅₀ of 15.2 nM) and TRA-1-81 cells (IC₅₀ of 5.1 nM) in cell lines SW1990GR, inhibits proliferations and cell viabilities of pancreatic cancer cells SW1990 and SW1990GR (IC₅₀ of 33.8 nM for SW1990 and 40.8 for SW1990GR).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cymarin inhibits growth of neonate Trichoplusia ni larvae with EC₅₀ of 157 p.p.m, reveals an antifeedant effect against Trichoplusia ni larva with a DC₅₀ of 10.8 μg/cm^2[3].
Cymarin (2 mg/kg, i.p., twice a week for 3 weeks) inhibits tumor growth, eliminates TRA-1-60 cells and decreases chemoresistance in SW1990 xenografted nude mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

548.66

C₃₀H₄₄O₉

508-77-0

Solid

White to off-white

O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O[C@@]4([H])C[C@@H]([C@H](O)[C@@H](C)O4)OC)CC2)O)([H])[C@@]5([C@@](C)([C@@H](C(CO6)=CC6=O)CC5)CC3)O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152(2):475-480.  [Content Brief]

  [2]. Li Q, et al., Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes Genet Syst. 2023 Oct 24;98(4):161-169.  [Content Brief]

  [3]. Akhtar Y, et al., Comparative growth inhibitory and antifeedant effects of plant extracts and pure allelochemicals on four phytophagous insect species. J Applied Entomology. 10 February 2004.128,32-38.

  [4]. Tan L, et al., A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. J Mol Cell Biol. 2023 Nov 27;15(6):mjad039.  [Content Brief]