1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Antitumor agent-63

Antitumor agent-63 

Cat. No.: HY-146094
Handling Instructions

Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition.

For research use only. We do not sell to patients.

Antitumor agent-63 Chemical Structure

Antitumor agent-63 Chemical Structure

CAS No. : 1627600-90-1

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Description

Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition[1].

IC50 & Target

Top1

 

In Vitro

Antitumor agent-63 (Compound 40) shows cytotoxicity activities with IC50 values of 1.2, 0.8, 30.5 and >100 µM against HepG2, HCT-116, SW1990 and HEK-293, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

846.79

Formula

C38H46N4O18

CAS No.
SMILES

O[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O1)CO)O)OC(N)=O)[[email protected]]1O[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](O2)CO)O)O)[[email protected]]2OCCOCCNC(O[[email protected]]3(C4=C(COC3=O)C(N5C(C6=NC7=CC=CC=C7C=C6C5)=C4)=O)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Antitumor agent-63
Cat. No.:
HY-146094
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