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Cat. No.: HY-155303

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DCLK1-IN-2

DCLK1-IN-2 (compound I-5) is a potent DCLK1 inhibitor with an IC₅₀ of 171.3  nM. DCLK1-IN-2 shows remarkable antiproliferative effects on SW1990 cell lines (IC₅₀ of 0.6 μM) and in vivo antitumor potency.

For research use only. We do not sell to patients.

CAS No.: 2978517-43-8
Formula: C₂₆H₃₂N₈O₃S
Molecular Weight:536.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DCLK1-IN-2 Chemical Structure

CAS No.: 2978517-43-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CAKI-1	IC₅₀	10.1 μM Compound: I-5	Antiproliferative activity against human CAKI-1 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay Antiproliferative activity against human CAKI-1 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay	[PMID: 37862816]
HCT-116	IC₅₀	3 μM Compound: I-5	Antiproliferative activity against human HCT-116 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay	[PMID: 37862816]
SW1990	IC₅₀	0.6 μM Compound: I-5	Antiproliferative activity against human SW1990 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay Antiproliferative activity against human SW1990 cells assessed as inhibition cell proliferation incubated for 6 days by MTT assay	[PMID: 37862816]

Chemical Information

CAS No. 2978517-43-8
Molecular Weight 536.65
Formula C₂₆H₃₂N₈O₃S
SMILES

CC(C)S(C1=C(NC2=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=NC5=C2N=CN5)C=CC=C1)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yuepeng Chen, et al. Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer. European Journal of Medicinal Chemistry. 7 October 2023, 115846.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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