Phellodendrine chloride

Cat. No.: HY-N0735 Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis . Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis.

For research use only. We do not sell to patients.

Phellodendrine chloride Chemical Structure

CAS No. : 104112-82-5

Size	Price	Stock	Quantity
1 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
20 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phellodendrine chloride:

Phellodendrine Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis ^[1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis^[2].

Molecular Weight

377.86

Appearance

Solid

Formula

C₂₀H₂₄ClNO₄

CAS No.

104112-82-5

SMILES

C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC(O)=C(OC)C=C4C2.[Cl-]

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (132.32 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6465 mL	13.2324 mL	26.4648 mL
5 mM	0.5293 mL	2.6465 mL	5.2930 mL
10 mM	0.2646 mL	1.3232 mL	2.6465 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 5 mg/mL (13.23 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 5 mg/mL (13.23 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 5 mg/mL (13.23 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.79%

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Data Sheet (273 KB) SDS (393 KB)

COA (250 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34. [Content Brief]

[2]. Su S, Wang X, Xi X, et al. Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis. J Cell Mol Med. 2021;25(12):5707-5720. [Content Brief]