1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Compound 48/80 trihydrochloride

Compound 48/80 trihydrochloride (Synonyms: C48/80 trihydrochloride)

Cat. No.: HY-130592
Handling Instructions

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .

For research use only. We do not sell to patients.

Compound 48/80 trihydrochloride Chemical Structure

Compound 48/80 trihydrochloride Chemical Structure

CAS No. : 848035-21-2

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Description

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3].

In Vitro

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter[3].
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old Wistar male rats (fasted for 24 hours)[3]
Dosage: 0.75 mg/kg
Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h
Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
Molecular Weight

629.10

Formula

C₃₂H₄₈Cl₃N₃O₃

CAS No.

848035-21-2

SMILES

CNCCC1=CC(CC2=CC(CCNC)=CC=C2OC)=C(OC)C(CC3=CC(CCNC)=CC=C3OC)=C1.[H]Cl.[H]Cl.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Compound 48/80 trihydrochlorideC48/80 trihydrochloridePhospholipasehumanplateletaggregationhistamineoxidativestressInhibitorinhibitorinhibit

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Compound 48/80 trihydrochloride
Cat. No.:
HY-130592
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