Phellodendrine chloride (Standard)
Phellodendrine chloride (Standard) is the analytical standard of Phellodendrine chloride (HY-N0735). Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway.
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- CAS No.: 104112-82-5
- Formule: C20H24ClNO4
- Masse moléculaire:377.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 104112-82-5
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Masse moléculaire 377.86
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Formule C20H24ClNO4
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SMILES
C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC(O)=C(OC)C=C4C2.[Cl-]
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34. [Content Brief]
[2]. Su S, Wang X, Xi X, et al. Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis. J Cell Mol Med. 2021;25(12):5707-5720. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phellodendrine chloride (Standard) Related Classifications
HY-N0735R Related Classifications
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- Phellodendrine chloride (Standard)
- 104112-82-5
- Reference Standards
- Autophagy
- mTOR
- AMPK
- Apoptosis
- STAT
- Interleukin Related
- PKC
- p38 MAPK
- NF-κB
- COX
- Reactive Oxygen Species (ROS)
- PI3K
- Akt
- MMP
- KRAS mutated pancreatic cancers
- Macropinocytosis
- Glutamine metabolism
- Mitochondrial apoptosis
- Autophagy
- Network pharmacology
- Phellodendrine
- Ulcerative colitis
- Inhibitor
- inhibitor
- inhibit