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    Metabolic Enzyme/Protease
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    Endogenous Metabolite
  3. Uric acid sodium

Uric acid sodium 

Cat. No.: HY-B2130A Purity: 99.55%
Handling Instructions

Uric acid sodium, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.

For research use only. We do not sell to patients.

Uric acid sodium Chemical Structure

Uric acid sodium Chemical Structure

CAS No. : 1198-77-2

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200 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Uric acid sodium, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy[2].
Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57BL/6J mice[2]
Dosage: 250 mg/kg body weight
Administration: P.o.
Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
Molecular Weight

190.09

Formula

C₅H₃N₄NaO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (26.30 mM; ultrasonic and warming and adjust pH to 6 with HCl and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2607 mL 26.3033 mL 52.6067 mL
5 mM 1.0521 mL 5.2607 mL 10.5213 mL
10 mM 0.5261 mL 2.6303 mL 5.2607 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Uric acid sodium
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HY-B2130A
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