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  5. Uric acid sodium

Uric acid sodium  (Synonyms: Monosodium urate)

Cat. No.: HY-B2130A Purity: 99.58%
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Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.

For research use only. We do not sell to patients.

CAS No. : 1198-77-2

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Customer Review

Based on 21 publication(s) in Google Scholar

Other Forms of Uric acid sodium:

Uric acid sodium Related Antibodies

Top Publications Citing Use of Products

    Uric acid sodium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(16):e2415041.  [Abstract]

    Immunofluorescence analysis of hair cells (HCs) with or without Uric acid (UA; 1, 2, 4 mM) at different concentrations for 24 h. Myosin 7a positive HCs are shown in red, and nuclei are labeled in blue.

    Uric acid sodium purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2025 Oct 2;30(1):109.  [Abstract]

    The TEAC (top) and MDA content (bottom) were measured after co-treatment with RSL3 (MHCC97H: 0.5 µM; SJSA-1: 1 µM; LoVo: 5 µM) and Uric acid (UA; 500 µM) for 24 h. TEAC values were normalized to Trolox standards.

    Uric acid sodium purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Sep 23:480:135938.  [Abstract]

    Representative Western blots of PPARγ and quantification of its protein level in different groups of HK2 cells with Uric acid (UA; 400 μM; 48 h).

    Uric acid sodium purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Sep 23:480:135938.  [Abstract]

    Representative IF images of PPARγ (green)/DAPI (blue) in HK2 cells with Uric acid (UA; 400 μM; 48 h).

    Uric acid sodium purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Sep 23:480:135938.  [Abstract]

    Representative cell viability detected by CCK-8 in different groups of HK2 cells. Bixin (0-640 μM) without or with 400 μM Uric acid (UA) for 48 h.

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    • Purity & Documentation

    • References

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    Description

    Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

    IC50 & Target[1]

    Human Endogenous Metabolite

     

    In Vitro

    Uric acid (400 μM; 48 hours) sodium protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
    Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium is higher than that in cells treated with indomethacin alone. Uric acid sodium has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Uric acid sodium Related Antibodies
    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Uric acid (250 mg/kg; p.o.) sodium ameliorates indomethacin-induced enteropathy[2].
    Oral administration of uric acid sodium decreases ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Eight-week-old male C57BL/6J mice[2]
    Dosage: 250 mg/kg body weight
    Administration: P.o.
    Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
    Molecular Weight

    190.09

    Formula

    C5H3N4NaO3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(N1)NC2=C(N=C(O[Na])N2)C1=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    1M NaOH : 8.33 mg/mL (43.82 mM; ultrasonic and warming and adjust pH to 12 with 1M NaOH and heat to 60°C)

    DMSO : 3.03 mg/mL (15.94 mM; ultrasonic and warming and adjust pH to 4 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.2607 mL 26.3033 mL 52.6067 mL
    5 mM 1.0521 mL 5.2607 mL 10.5213 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC/saline water

      Solubility: 40 mg/mL (210.43 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.61%

    SDS (393 KB)

    COA (248 KB) RP-HPLC (208 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / 1M NaOH 1 mM 5.2607 mL 26.3033 mL 52.6067 mL 131.5167 mL
    5 mM 1.0521 mL 5.2607 mL 10.5213 mL 26.3033 mL
    10 mM 0.5261 mL 2.6303 mL 5.2607 mL 13.1517 mL
    15 mM 0.3507 mL 1.7536 mL 3.5071 mL 8.7678 mL
    1M NaOH 20 mM 0.2630 mL 1.3152 mL 2.6303 mL 6.5758 mL
    25 mM 0.2104 mL 1.0521 mL 2.1043 mL 5.2607 mL
    30 mM 0.1754 mL 0.8768 mL 1.7536 mL 4.3839 mL
    40 mM 0.1315 mL 0.6576 mL 1.3152 mL 3.2879 mL
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    Uric acid sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Uric acid1198-77-2Monosodium urateReactive Oxygen Species (ROS)Endogenous Metabolitesingletoxygenperoxynitritelipidperoxidationantioxidantenteropathy oxidativestresscytotoxicityInhibitorinhibitorinhibit

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