KRAS G12D inhibitor 8
KRAS G12D inhibitor 8 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 8 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021107160A1, compound 2).
For research use only. We do not sell to patients.
- CAS No.: 2648221-05-8
- Formula: C32H38BrFN6O2
- Molecular Weight:637.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-427 | IC50 |
0.54 μM
Compound: 2
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Antiproliferative activity against human A427 cells expressing KRAS G12D mutant assessed as inhibition of cell growth measured after 3 days by CellTiter-Glo assay
Antiproliferative activity against human A427 cells expressing KRAS G12D mutant assessed as inhibition of cell growth measured after 3 days by CellTiter-Glo assay
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[PMID: 34413947] |
Chemical Information
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CAS No. 2648221-05-8
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Molecular Weight 637.59
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Formula C32H38BrFN6O2
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SMILES
OC1=CC(C=CC=C2Br)=C2C(N3CC4=NC(OCC5(CC5)CN6C[C@@H](CC6)F)=NC(N7CC8NC(CC8)C7)=C4CC3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS G12D inhibitor 8 Related Classifications
HY-143599 Related Classifications
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