KRAS G12D inhibitor 16
KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 2648221-12-7
- Formula: C32H39IN6O3
- Molecular Weight:682.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRas G12D 0.7 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| A-427 | IC50 |
0.35 μM
Compound: 9
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Antiproliferative activity against human A427 cells expressing KRAS G12D mutant assessed as inhibition of cell growth measured after 3 days by CellTiter-Glo assay
Antiproliferative activity against human A427 cells expressing KRAS G12D mutant assessed as inhibition of cell growth measured after 3 days by CellTiter-Glo assay
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[PMID: 34413947] |
KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC50 value of 0.7 nM[1].
KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC50 value of 0.35 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2648221-12-7
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Molecular Weight 682.59
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Formula C32H39IN6O3
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SMILES
IC1=CC=CC2=C1C(N3CC(N=C(OCC4(CC4)CN5CCOCC5)N=C6N7C[C@H]8N[C@H](CC8)C7)=C6CC3)=CC(O)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS G12D inhibitor 16 Related Classifications
HY-148260 Related Classifications
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