2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 16

KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC).

For research use only. We do not sell to patients.

KRAS G12D inhibitor 16 Chemical Structure

KRAS G12D inhibitor 16 Chemical Structure

CAS No. : 2648221-12-7

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KRAS G12D inhibitor 16 Related Antibodies

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Description

KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].

IC50 & Target

KRas G12D

0.7 nM (IC50)

In Vitro

KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC50 value of 0.7 nM[1].
KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC50 value of 0.35 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS G12D inhibitor 16 Related Antibodies
Molecular Weight

682.59

Formula

C32H39IN6O3
CAS No.
SMILES

IC1=CC=CC2=C1C(N3CC(N=C(OCC4(CC4)CN5CCOCC5)N=C6N7C[C@H]8N[C@H](CC8)C7)=C6CC3)=CC(O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRAS G12D inhibitor 16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D inhibitor 162648221-12-7RasantitumorKRAS G12Dinhibitorypancreatic ductal adenocarcinomas (PDAC)colon and rectal carcinomas (CRC)non-small cell lung carcinomas (NSCLC)Inhibitorinhibitorinhibit

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