KRAS G12D inhibitor 16
KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 2648221-12-7
- Formula: C32H39IN6O3
- Molecular Weight:682.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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KRas G12D 0.7 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| A-427 | IC50 |
0.35 μM
Compound: 9
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Antiproliferative activity against human A427 cells expressing KRAS G12D mutant assessed as inhibition of cell growth measured after 3 days by CellTiter-Glo assay
Antiproliferative activity against human A427 cells expressing KRAS G12D mutant assessed as inhibition of cell growth measured after 3 days by CellTiter-Glo assay
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[PMID: 34413947] |
In Vitro
KRAS G12D inhibitor 16 has inhibitory activity for G12 with an IC50 value of 0.7 nM[1].
KRAS G12D inhibitor 16 shows growth inhibition activity KRAS-G12D mutant cell line (A-427) with an IC50 value of 0.35 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2648221-12-7
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Molecular Weight 682.59
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Formula C32H39IN6O3
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SMILES
IC1=CC=CC2=C1C(N3CC(N=C(OCC4(CC4)CN5CCOCC5)N=C6N7C[C@H]8N[C@H](CC8)C7)=C6CC3)=CC(O)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS G12D inhibitor 16 Related Classifications
HY-148260 Related Classifications
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