2648221-12-7
Chemical Structure
KRAS G12D inhibitor 16
- CAS 番号: 2648221-12-7
- Formula:C32H39IN6O3
- Molecular Weight:682.59
IUPAC Name: 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-((1-(morpholinomethyl)cyclopropyl)methoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-5-iodonaphthalen-2-ol
InChIKey: MWSOTQXCCZLZSY-ZRZAMGCNSA-N
SMILES: IC1=CC=CC2=C1C(N3CC(N=C(OCC4(CC4)CN5CCOCC5)N=C6N7C[C@H]8N[C@H](CC8)C7)=C6CC3)=CC(O)=C2
Biological Activity: KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC)[1].
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KRAS G12D inhibitor 16 | KRAS G12D inhibitor 16 is a KRAS G12D inhibitor. KRAS G12D inhibitor 16 has inhibitory activity against KRAS G12D and KRAS G12D mutation with IC50 value of 0.7 nM and 0.35 μM, respectively. KRAS G12D inhibitor 16 can be used for the research of many malignant tumor, such as pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), non-small cell lung carcinomas (NSCLC). | |||||||||||||||||||||
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Keywords
