KRAS G12C inhibitor 15
Based on 1 Customer Validation
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM.
For research use only. We do not sell to patients.
- Purity: 98.47%
- CAS No.: 2349393-21-9
- Formula: C25H21ClF2N4O3
- Molecular Weight:498.91
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRas G12C 5 nM (IC50) |
Chemical Information
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CAS No. 2349393-21-9
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Appearance Solid
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Molecular Weight 498.91
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Formula C25H21ClF2N4O3
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Color White to yellow
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SMILES
FC1=C(N=CC(N2C)=C3N4[C@H](CN(C(C=C)=O)[C@H](C)C4)C2=O)C3=CC(Cl)=[C@@]1[C@@]5=C(F)C=CC=C5O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 193.33 mg/mL (387.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0044 mL | 10.0218 mL | 20.0437 mL | 50.1092 mL |
| 5 mM | 0.4009 mL | 2.0044 mL | 4.0087 mL | 10.0218 mL | |
| 10 mM | 0.2004 mL | 1.0022 mL | 2.0044 mL | 5.0109 mL | |
| 15 mM | 0.1336 mL | 0.6681 mL | 1.3362 mL | 3.3406 mL | |
| 20 mM | 0.1002 mL | 0.5011 mL | 1.0022 mL | 2.5055 mL | |
| 25 mM | 0.0802 mL | 0.4009 mL | 0.8017 mL | 2.0044 mL | |
| 30 mM | 0.0668 mL | 0.3341 mL | 0.6681 mL | 1.6703 mL | |
| 40 mM | 0.0501 mL | 0.2505 mL | 0.5011 mL | 1.2527 mL | |
| 50 mM | 0.0401 mL | 0.2004 mL | 0.4009 mL | 1.0022 mL | |
| 60 mM | 0.0334 mL | 0.1670 mL | 0.3341 mL | 0.8352 mL | |
| 80 mM | 0.0251 mL | 0.1253 mL | 0.2505 mL | 0.6264 mL | |
| 100 mM | 0.0200 mL | 0.1002 mL | 0.2004 mL | 0.5011 mL |
KRAS G12C inhibitor 15 Related Classifications
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