1. GPCR/G Protein MAPK/ERK Pathway
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  3. KRAS G12C inhibitor 15

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM.

For research use only. We do not sell to patients.

KRAS G12C inhibitor 15 Chemical Structure

KRAS G12C inhibitor 15 Chemical Structure

CAS No. : 2349393-21-9

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1 mg USD 350 In-stock
5 mg USD 920 In-stock
10 mg USD 1500 In-stock
25 mg USD 3100 In-stock
50 mg USD 5000 In-stock
100 mg USD 8000 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM[1].

IC50 & Target[1]

KRas G12C

5 nM (IC50)

Molecular Weight

498.91

Formula

C25H21ClF2N4O3

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

FC1=C(N=CC(N2C)=C3N4[C@H](CN(C(C=C)=O)[C@H](C)C4)C2=O)C3=CC(Cl)=[C@@]1[C@@]5=C(F)C=CC=C5O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 193.33 mg/mL (387.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0044 mL 10.0218 mL 20.0437 mL
5 mM 0.4009 mL 2.0044 mL 4.0087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0044 mL 10.0218 mL 20.0437 mL 50.1092 mL
5 mM 0.4009 mL 2.0044 mL 4.0087 mL 10.0218 mL
10 mM 0.2004 mL 1.0022 mL 2.0044 mL 5.0109 mL
15 mM 0.1336 mL 0.6681 mL 1.3362 mL 3.3406 mL
20 mM 0.1002 mL 0.5011 mL 1.0022 mL 2.5055 mL
25 mM 0.0802 mL 0.4009 mL 0.8017 mL 2.0044 mL
30 mM 0.0668 mL 0.3341 mL 0.6681 mL 1.6703 mL
40 mM 0.0501 mL 0.2505 mL 0.5011 mL 1.2527 mL
50 mM 0.0401 mL 0.2004 mL 0.4009 mL 1.0022 mL
60 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL
80 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6264 mL
100 mM 0.0200 mL 0.1002 mL 0.2004 mL 0.5011 mL
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KRAS G12C inhibitor 15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KRAS G12C inhibitor 15
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HY-125873
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