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  4. KRAS G12C inhibitor 15

KRAS G12C inhibitor 15 

Cat. No.: HY-125873 Purity: 99.55%
COA Handling Instructions

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM.

For research use only. We do not sell to patients.

KRAS G12C inhibitor 15 Chemical Structure

KRAS G12C inhibitor 15 Chemical Structure

CAS No. : 2349393-21-9

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5 mg USD 1250 In-stock
10 mg USD 1950 In-stock
25 mg USD 3900 In-stock
50 mg USD 6250 In-stock
100 mg USD 10000 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM[1].

IC50 & Target[1]

KRas G12C

5 nM (IC50)

Molecular Weight

498.91

Appearance

Solid

Formula

C25H21ClF2N4O3
CAS No.
SMILES

FC1=C(N=CC(N2C)=C3N4[[email protected]](CN(C(C=C)=O)[[email protected]](C)C4)C2=O)C3=CC(Cl)=[[email protected]@]1[[email protected]@]5=C(F)C=CC=C5O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 193.33 mg/mL (387.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0044 mL 10.0218 mL 20.0437 mL
5 mM 0.4009 mL 2.0044 mL 4.0087 mL
10 mM 0.2004 mL 1.0022 mL 2.0044 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

KRAS G12C inhibitor 152349393-21-9RasInhibitorinhibitorinhibit

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