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Cat. No.: HY-137971

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(±)-Spiro-oxanthromicin A

(±)-Spiro-oxanthromicin A (Compound 4), a polyketide, is a K-Ras inhibitor with an IC₅₀ of 26.7  μM. (±)-Spiro-oxanthromicin A can be isolated from soil-derived Streptomyces sp. (±)-Spiro-oxanthromicin A can mislocalize oncogenic mutant K-Ras from the plasma membrane of intact MDCK cells. (±)-Spiro-oxanthromicin A can be used for cancers research.

For research use only. We do not sell to patients.

CAS No.: 1616622-10-6
Formula: C₃₆H₂₆O₁₀
Molecular Weight:618.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

(±)-Spiro-oxanthromicin A Chemical Structure

CAS No.: 1616622-10-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Ras Isoforms :

Chemical Information

CAS No. 1616622-10-6
Molecular Weight 618.59
Formula C₃₆H₂₆O₁₀
SMILES

CC(C=C1C(C(C2=C3O)=CC=C3C)(CC=C(C(C4=C5C)=CC(O)=C5C(O)=O)C1=C6C4=O)C(C(C2=O)=C7C)=CC(O)=C7C(O)=O)=C6O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Streptomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Salim AA, et al. Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Org Biomol Chem. 2014 Jul 21;12(27):4872-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(±)-Spiro-oxanthromicin A

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(±)-Spiro-oxanthromicin A Related Classifications

HY-137971 Related Classifications