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Cat. No.: HY-163489

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pan-KRAS-IN-15

pan-KRAS-IN-15 (compound 58) is a pan-KRAS inhibitor. pan-KRAS-IN-15 can be used in pancreatic cancer research.

For research use only. We do not sell to patients.

CAS No.: 3034052-52-0
Formula: C₃₆H₃₇F₃N₆O₂
Molecular Weight:642.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

pan-KRAS-IN-15 Chemical Structure

CAS No.: 3034052-52-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

pan-KRAS-IN-15 (compound 58) is a pan-KRAS inhibitor. pan-KRAS-IN-15 can be used in pancreatic cancer research^[1].

IC₅₀ & Target

K-RAS

1.4 nM (IC₅₀)

All Ras Isoforms :

In Vitro

pan-KRAS-IN-15 shows significant inhibitory activity on human pancreatic cancer ASPC-I cells (IC₅₀=1.4 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034052-52-0
Molecular Weight 642.71
Formula C₃₆H₃₇F₃N₆O₂
SMILES

CC#CC1=C2C(N3C[C@@H](CC4)N[C@@H]4C3)=NC(OC[C@@]56CCCN5C[C@@H](C6)F)=NC2=C(C(C7=CC(O)=CC8=C7C(CC)=C(C=C8)F)=N1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ying Lei, et al. Kras mutant protein inhibitor, preparation method therefor, and use thereof.WO2024061333A1.2023-09-21

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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pan-KRAS-IN-15

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

pan-KRAS-IN-15 Related Classifications

HY-163489 Related Classifications