KRASG12C IN-14
KRASG12C IN-14 (compound 15) is an inhibitor targeting the KRAS G12C mutation. KRASG12C IN-14 inhibits CYPA-dependent KRAS-BRAF with an IC50 of 0.002 μM. KRASG12C IN-14 inhibits ERK phosphorylation in NCI-H358 cells with an IC50 of 0.002 μM.
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- Formule: C51H65F4N9O9S2
- Masse moléculaire:1088.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
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KRas G12C |
Chemical Information
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Masse moléculaire 1088.24
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Formule C51H65F4N9O9S2
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SMILES
O=C(OCC(C)(C)CC1=[C@@]([C@@]2=C([C@@H](OC)C)N=CC(N3CCOCC3)=C2)N(CC(F)(F)F)C4=C1C=C5C=C4)[C@H]6NN(C([C@@H](NC([C@H](C(C)C)N(C(N7CC(/C=C(S(C)(=O)=O)\F)C7)=O)C)=O)CC8=NC5=CS8)=O)CCC6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRASG12C IN-14 Related Classifications
HY-168013 Related Classifications
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