KRAS G12D inhibitor 22
KRAS G12D inhibitor 22 (compound 6) is a inhibitor of KRAS mutation. KRAS G12D inhibitor 22 has high activity (IC50＜100 nM), good selectivity and low toxicity.KRAS G12D inhibitor 22 can be used in breast cancer research.
For research use only. We do not sell to patients.
- Formula: C35H32F4N6O2
- Molecular Weight:644.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRas G12D <100 nM (IC50) |
KRAS G12D inhibitor 22 (0.08-20 μM; 72 h) has a good inhibitory effect on the growth of AGS cells (IC50＜500 nM)[1].
KRAS G12D inhibitor 22 shows high inhibitory effect on KRAS G12D protein (IC50＜100 nM)[1].
KRAS G12D inhibitor 22 (0.08-20 μM; 72 h) has batter anti-proliferation activity of ASPC-1 and AGS cells than that of MRTX1133 (HY-134813), and has better selection effect to other Kras G12C mutant cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AGS, AsPC-K, NCI-H358, MOLM13 cells
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Concentration:0.08-20 μM
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Incubation Time:72 h
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Result:Had good inhibitory effect on the growth of Kras, Gl2D mutant AGS, ASPC-1 cells.
Had weak inhibitory effect on the growth of KRASG12C-mutated cell line NCI-H358 and Kras wild-type cell line MOLMl3.
Pharmacokinetic Analysis in Male SD ratl[1]
| Route | Dose (mg/kg) | T1/2 (h) | Cmax (ng/mL) | Tmax (h) | CL (mL/min/kg) | Vss (L/kg) | AUG0_t (ng/mL h) | Bioavailability (%) |
| i.v. | 5 | 0.63 | 2163 | 0.08 | 96.4 | 3.5 | 1128 | / |
| i.p. | 3 | 1.03 | 177 | 0.25 | / | / | 255.8 | 37.79 |