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Cat. No.: HY-181883

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KRAS-IN-55

KRAS-IN-55 is a pan-KRAS inhibitor with IC₅₀ values of 4.3, 9.6 and 1.6 nM against KRAS^G12C, KRAS^G12D and KRAS^G12V, respectively. KRAS-IN-55 induces the formation of a new binding pocket on KRAS, thereby forming a high-affinity ternary complex with cyclophilin A (CYPA), inhibiting the interactions of KRAS with downstream effectors RAF and PI3K, and blocking oncogenic MAPK and PI3K signaling pathways. KRAS-IN-55 is applicable to cancer research such as colorectal cancer and non-small cell lung cancer.

For research use only. We do not sell to patients.

Formula: C₄₈H₅₈FN₉O₅S
Molecular Weight:892.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-55 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Ras Isoforms :

All Raf Isoforms :

All PI3K Isoforms :

All p38 MAPK Isoforms :

In Vitro

KRAS-IN-55 (Example 2) (72 h) inhibits the viability of KRAS^G12C, KRAS^G12D, and KRAS^G12V mutant cancer cells, with an IC₅₀ of 15.2 nM in NCI-H358 cells, 10.5 nM in AGS cells, 2.8 nM in SW620 cells^[1].
KRAS-IN-55 (0.0001-10 μM; 3 h) inhibits the interaction between KRAS^G12C, KRAS^G12D, KRAS^G12V and BRAF_rbd, with an IC₅₀ of 0.008 μM against KRAS^G12C, 0.044 μM against KRAS^G12D, and 0.010 μM against KRAS^G12V^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 892.09
Formula C₄₈H₅₈FN₉O₅S
SMILES

CCC1=[C@](N2CC(C)(COC([C@@H]3CCCN(C([C@H](CC4=NC(C5=C(C2=C1C=C5)F)=CS4)NC([C@H]6C[C@@H]6C7=CN=CC=C7)=O)=O)N3)=O)C)[C@]8=C(N=CC(N9CCN(CC9)C)=C8)[C@@H](OC)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen, Jianguo, et al. Preparation of macrocycle compounds for treatment of cancer as KRAS inhibitors. WO2026041636.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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KRAS-IN-55

All Ras Isoforms

All Raf Isoforms

All PI3K Isoforms

All p38 MAPK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS-IN-55 Related Classifications

HY-181883 Related Classifications