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Cat. No.: HY-184821

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KRAS G12C-IN-80

KRAS G12C-IN-80 is an orally active KRAS^G12C inhibitor. KRAS G12C-IN-80 exhibits antitumor activity in vivo. KRAS G12C-IN-80 can be used in research related to non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2925468-57-9
Formula: C₃₅H₃₃F₃N₆O₂
Molecular Weight:626.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS G12C-IN-80 Chemical Structure

CAS No.: 2925468-57-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

KRAS G12C-IN-80 is an orally active KRAS^G12C inhibitor. KRAS G12C-IN-80 exhibits antitumor activity in vivo. KRAS G12C-IN-80 can be used in research related to non-small cell lung cancer^[1].

IC₅₀ & Target^[1]

KRAS(G12C)

All Ras Isoforms :

In Vivo

KRAS G12C-IN-80 (Compound 1) (100 mg/kg; p.o.; once daily for 21 consecutive days) causes a significant decrease in bioluminescent signals relative to baseline in a CDX mouse model intracranially injected with NCI-H1373-Luc (KRAS G12C; TP53) non-small cell lung cancer cells, indicating significant tumor regression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice were inoculated intracranially with 0.3×10⁶ NCI-H1373-Luc tumor cells, which carry the firefly luciferase gene, in 3 μL PBS mixed with Matrigel (80:20) at the right frontal lobe using stereotaxic intracranial injection technique.^[1]
Dosage:

100 mg/kg
Administration:

PO; once a day; 21 days
Result:

Produced a significant reduction in bioluminescence signal compared to baseline, indicating robust tumor regression.
On treatment day 21, achieved a mean bioluminescence signal of 9.15×10⁶ photons/second in the treatment group, whereas the vehicle group exhibited a mean signal of 4.49×10⁹ photons/second.
Resulted in approximately 99.8% inhibition of tumor growth compared to the vehicle control group.
Demonstrated sustained antitumor activity throughout the 21-day treatment period, with the bioluminescence signal continuing to decrease from day 7 through day 21.

Chemical Information

CAS No. 2925468-57-9
Molecular Weight 626.67
Formula C₃₅H₃₃F₃N₆O₂
SMILES

CN([C@H]1CN(CC1)C(C=C)=O)C2=NC(OC[C@@]34N(CCC4)C[C@@H](C3)F)=NC5=C2C=NC(C6=CC=CC7=C6C(C#C)=C(F)C=C7)=C5F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. WANG, Yan, et al. Pyridopyrimidine derivative as KRAS G12C inhibitor for the treatment of brain metastasis. WO2025179058 A1

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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KRAS G12C-IN-80

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS G12C-IN-80 Related Classifications

HY-184821 Related Classifications