K-Ras ligand-Linker Conjugate 4

Cat. No.: HY-130822 Pureza: 98.76%: Ficha de datos
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K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

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K-Ras ligand-Linker Conjugate 4 Estructura química

No. CAS : 2378261-83-5

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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Descripciòn	K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells^[1].
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. K-Ras ligand-Linker Conjugate 4 Related Antibodies
Peso molecular	697.82
Fòrmula	C₃₅H₅₁N₇O₈
No. CAS	2378261-83-5
Appearance	Oil
Color	Colorless to light yellow
SMILES	O=C(N1[C@@H](CC#N)CN(C2=C3C(CNCC3)=NC(OC[C@H]4N(C)C[C@H](OCCOCCOCCOCCO)C4)=N2)CC1)OCC5=CC=CC=C5
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureza y Documentación	Purity: 98.76% Select Batch: Ficha de datos (264 KB) SDS (393 KB) COA (246 KB) HNMR (390 KB) RP-HPLC (267 KB) LCMS (99 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.