2. PROTAC
  3. Target Protein Ligand-Linker Conjugates
  4. K-Ras ligand-Linker Conjugate 4

K-Ras ligand-Linker Conjugate 4 

Cat. No.: HY-130822 Purity: 95.06%
COA Handling Instructions

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K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

For research use only. We do not sell to patients.

K-Ras ligand-Linker Conjugate 4 Chemical Structure

K-Ras ligand-Linker Conjugate 4 Chemical Structure

CAS No. : 2378261-83-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in Ethanol USD 146 In-stock
Oil
5 mg USD 95 In-stock
10 mg USD 155 In-stock
25 mg USD 310 In-stock
50 mg USD 500 In-stock
100 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

K-Ras ligand-Linker Conjugate 4 Related Antibodies

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Description

K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K-Ras ligand-Linker Conjugate 4 Related Antibodies
Molecular Weight

697.82

Formula

C35H51N7O8
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(N1[C@@H](CC#N)CN(C2=C3C(CNCC3)=NC(OC[C@H]4N(C)C[C@H](OCCOCCOCCOCCO)C4)=N2)CC1)OCC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (71.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4330 mL 7.1652 mL 14.3303 mL
5 mM 0.2866 mL 1.4330 mL 2.8661 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 1.4330 mL 7.1652 mL 14.3303 mL 35.8259 mL
5 mM 0.2866 mL 1.4330 mL 2.8661 mL 7.1652 mL
10 mM 0.1433 mL 0.7165 mL 1.4330 mL 3.5826 mL
15 mM 0.0955 mL 0.4777 mL 0.9554 mL 2.3884 mL
20 mM 0.0717 mL 0.3583 mL 0.7165 mL 1.7913 mL
25 mM 0.0573 mL 0.2866 mL 0.5732 mL 1.4330 mL
30 mM 0.0478 mL 0.2388 mL 0.4777 mL 1.1942 mL
40 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8956 mL
50 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7165 mL
60 mM 0.0239 mL 0.1194 mL 0.2388 mL 0.5971 mL
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K-Ras ligand-Linker Conjugate 4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras ligand-Linker Conjugate 42378261-83-5Target Protein Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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