KRASG12D-IN-5
KRASG12D-IN-5 (Compound 241) is an orally active KRAS(G12D) inhibitor with an IC50 of 11 nM. KRASG12D-IN-5 has potent anticancer activity with no significant cytotoxicity against BxPC-3 (WT), KRAS mutation AsPC-1 (G12D) and MIAPaCa-2 cells (G12C) with CC50s of 10.37, 0.76 and 0.3 μM, respectively. KRASG12D-IN-5 can be used for cancer research, such as lung, pancreatic and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 2933935-13-6
- Formula: C34H31F5N6O2
- Molecular Weight:650.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KRAS(G12D) 11 nM (IC50) |
| Species | Dose | Route | AUClast | T1/2 | F |
|---|---|---|---|---|---|
| Mice | 2 mg/kg | i.v. | 349 ng·h/mL | 2.42 h | 17.1 % |
| Mice | 30 mg/kg | p.o. | 922 ng·h/mL | 1.44 h | 17.1 % |
Chemical Information
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CAS No. 2933935-13-6
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Molecular Weight 650.64
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Formula C34H31F5N6O2
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SMILES
OC1=CC2=C(C(C#C)=C(C=C2)F)C(C3=C(F)C4=C(C=N3)C(N5[C@H](C(F)F)[C@H]6CC[C@](C5)([H])N6)=NC(OC[C@]78C[C@@H](F)CN7CCC8)=N4)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRASG12D-IN-5 Related Classifications
HY-174243 Related Classifications
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