BJP-06-005-3

BJP-06-005-3 is a highly selective peptide-based covalent Pin1 inhibitor that achieves potent Pin1 inhibition with an IC₅₀ of 48 nM through specific covalent modification of the active site Cys113 residue^[1].
BJP-06-005-3 (12 h) is a high-affinity covalent binder of recombinant Pin1 with an apparent K_i of 15 nM following 12 h incubation^[2].
BJP-06-005-3 (12 h) potently inhibits the enzymatic isomerase activity of recombinant Pin1 with an apparent K_i of 48 nM^[2].
BJP-06-005-3 (4 days) impairs 3D spheroid transformation in a Pin1-selective manner in PATU-8988T PDAC cells^[2].
BJP-06-005-3 (10 μM; 4 h) induces broad transcriptional remodeling in PATU-8988T PDAC cells after 4 h of treatment, with Myc target genes ranked among the most highly enriched transcription factor-associated gene sets^[2].
BJP-06-005-3 potently impairs KRAS-mutated PDAC cell function by disrupting Pin1-dependent downstream pathways and driving degradation of oncogenic mutant KRAS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.