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Results for "

Pin1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PIN1 (9) Amyloid-β (1) Bacterial (1) Biochemical Assay Reagents (2) Fluorescent Dye (1) MicroRNA (2) Small Interfering RNA (siRNA) (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (11) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: PIN1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116716

PIN1 inhibitor API-1	MicroRNA	Cancer
PIN1 inhibitor API-1 is a specific *Pin1* (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC₅₀ of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development ^[1].

HY-49597

Pin1 modulator 1	Wnt β-catenin	Cancer
Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets β-Catenin and inhibits the Wnt pathway. Pin1 modulator 1 can be used in the study of Wnt-mediated related diseases, such as cancer ^[1].

HY-139361

Sulfopin 1 Publications Verification Pin1-3	PIN1	Cancer
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of *Pin1* with an apparent K_i of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors ^[1].

HY-147710

PIN1 inhibitor 2	MicroRNA	Cancer
PIN1 inhibitor 2 (compound 12) is a potent *PIN1* inhibitor. PIN1 inhibitor 2 shows antitumor activity with an IC₅₀ of 9.55 µM for MCF7 cells. PIN1 inhibitor 2 has the potential for the research of breast cancer ^[1].

HY-RS10557

PIN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIN1 Human Pre-designed siRNA Set A PIN1 Human Pre-designed siRNA Set A

HY-145880

Elongation factor P-IN-1	Bacterial	Infection
Elongation factor P-IN-1 is a potent inhibitor elongation factor P (EFP). Elongation factor P-IN-1 is a β-lysine derivative compound. Elongation factor P-IN-1 affects the proliferation rates of E. coli ^[1].

HY-19771

amyloid P-IN-1	Amyloid-β	Cancer
amyloid P-IN-1 is used in the research of diseases or disorders wherein depletion of serum amyloid P component (SAP), including amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.

HY-143902

*ZL-Pin01*	PIN1	Cancer
ZL-Pin01 is a high potent covalent *Pin1* (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC₅₀ of 1.33 μM ^[1].

HY-143903

*ZL-Pin13*	PIN1	Cancer
ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the *Pin1* (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC₅₀ of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells ^[1].

HY-123847

KPT-6566	PIN1	Cancer
KPT-6566 is a selective and covalent prolyl isomerase *PIN1* inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades *PIN1. KPT-6566 shows an IC₅₀* value of 640 nM and a K_i value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer ^[1].

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc ^[1] .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc ^[1] .

HY-153675

BCPA	PIN1	Metabolic Disease
BCPA is a *Pin1* regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research ^[1].

HY-P3480

H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA	Fluorescent Dye	Others
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins ^[1] .

HY-P4359

Suc-AEPF-AMC

PIN1 Others

Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase ^[1].
HY-128034

PPIase-Parvulin inhibitor

PIN1 Cancer

PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 with IC₅₀s of 1.5 and 1.0 µM, respectively ^[1].

Suc-AEPF-AMC	PIN1	Others
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase ^[1].

PPIase-Parvulin inhibitor	PIN1	Cancer
PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases *Pin1* and *Pin4* with IC₅₀s of 1.5 and 1.0 µM, respectively ^[1].

HY-137122

3-Pyridine toxoflavin	PIN1	Inflammation/Immunology
3-Pyridine toxoflavin (compound 49) is a *PIN1* inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder ^[1].

HY-128592

TAB29	PIN1	Cancer
TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC₅₀ of 874 nM, possesses therapeutic potential for human cancers ^[1].

HY-146695

S100P-IN-1

Others Cancer

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC₅₀ of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells ^[1].

S100P-IN-1	Others	Cancer
S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC₅₀ of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells ^[1].

HY-131062

yGsy2p-IN-1	Others	Metabolic Disease
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC₅₀ of 2.75 µM and a K_i of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) ^[1].

Cat. No.	Product Name	Type

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc ^[1] .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc ^[1] .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc ^[1] .

HY-P3480

H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA	Fluorescent Dye	Others
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins ^[1] .

HY-P4359

Suc-AEPF-AMC

PIN1 Others

Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase ^[1].

Suc-AEPF-AMC	PIN1	Others
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase ^[1].

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P76547

	PIN1 Protein, Human (His) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Rotamase Pin1; Pin1	Human	E. coli
	The PIN1 protein is a peptidyl-prolyl cis/trans isomerase that complexly regulates multiple cellular processes by binding and isomerizing phosphorylated Ser/Thr-Pro motifs. This molecular switch induces conformational changes in phosphorylated proteins that affect mitosis, kinase activity, oncogene transactivation, centrosome amplification, and cell transformation. PIN1 Protein, Human (His) is the recombinant human-derived PIN1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PIN1 Protein, Human (His) is 163 a.a., with molecular weight of ~19 kDa.

HY-P76546

	PIN1 Protein, Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Rotamase Pin1; Pin1	Human	E. coli
	The PIN1 protein is a peptidyl-prolyl cis/trans isomerase that complexly regulates multiple cellular processes by binding and isomerizing phosphorylated Ser/Thr-Pro motifs. This molecular switch induces conformational changes in phosphorylated proteins that affect mitosis, kinase activity, oncogene transactivation, centrosome amplification, and cell transformation. PIN1 Protein, Human is the recombinant human-derived PIN1 protein, expressed by E. coli , with tag free. The total length of PIN1 Protein, Human is 163 a.a., with molecular weight of ~18 kDa.


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HY-P81890

PIN1 Antibody (YA1635)

DOD; UBL5
WB, ICC/IF Human, Mouse, Rat

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