ZL-Pin13
Based on 1 Customer Validation
ZL-Pin13 is a covalent Pin1 inhibitor. ZL-Pin13 modifies Cys113, blocking Pin1-substrate interactions and peptidyl-prolyl cis/trans isomerase activity. ZL-Pin13 induces partial Pin1 degradation and downregulates MCL-1, cyclin D1, and c-Myc at both the protein and transcriptional levels. ZL-Pin13 can be used in research on triple-negative breast cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.87%
- CAS. Nr.: 2883498-73-3
- Formel: C24H23ClN2O3S
- Molecular Weight:454.97
-
Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
|
MCL1 |
Pin1 |
Cyclin D1 |
c-Myc |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-468 | IC50 |
1.9 μM
|
Antiproliferative activity against human MDA-MB-468 cells assessed as viability reduction after 3 days by Cell Titer-Glo assay.
Antiproliferative activity against human MDA-MB-468 cells assessed as viability reduction after 3 days by Cell Titer-Glo assay.
|
35089030 |
| MDA-MB-231 | IC50 |
2.8 μM
|
Antiproliferative activity against human MDA-MB-231 cells assessed as viability reduction after 3 days by Cell Titer-Glo assay.
Antiproliferative activity against human MDA-MB-231 cells assessed as viability reduction after 3 days by Cell Titer-Glo assay.
|
35089030 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-468
-
Concentration:0.25; 0.5; 1; 2; 4 μM
-
Incubation Time:2 days; fresh compound every 48 h
-
Result:Significantly inhibited colony formation in MDA-MB-468 cells.
-
Cell Line:MDA-MB-231
-
Concentration:2.5; 5; 10; 15 μM
-
Incubation Time:16 h
-
Result:ZL-Pin13 at 5 and 10 μM dose-dependently caused partial Pin1 degradation following a 16 h exposure.
MCL-1, cyclin D1, and c-Myc exhibited notable decreases at the protein level.
In PIN1 knockdown cells, ZL-Pin13 did not further affect the levels of cyclin D1, MCL-1, c-Myc, and Pin1.
Chemical Information
-
CAS. Nr. 2883498-73-3
-
Appearance Solid
-
Molecular Weight 454.97
-
Formel C24H23ClN2O3S
-
Color White to off-white
-
SMILES
O=C(CSC12CCN(CC2)C(CCl)=O)N1CC3=CC=C(O3)C4=CC=CC5=C4C=CC=C5
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (219.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
-
Data Sheet (279 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). Journal of medicinal chemistry. 2022 Feb 10;65(3):2174-2190. [Content Brief]
[2]. Tian M, et al. Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors. ACS medicinal chemistry letters. 2025 Jan 09;16(1):101-108. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1979 mL | 10.9897 mL | 21.9795 mL | 54.9487 mL |
| 5 mM | 0.4396 mL | 2.1979 mL | 4.3959 mL | 10.9897 mL | |
| 10 mM | 0.2198 mL | 1.0990 mL | 2.1979 mL | 5.4949 mL | |
| 15 mM | 0.1465 mL | 0.7326 mL | 1.4653 mL | 3.6632 mL | |
| 20 mM | 0.1099 mL | 0.5495 mL | 1.0990 mL | 2.7474 mL | |
| 25 mM | 0.0879 mL | 0.4396 mL | 0.8792 mL | 2.1979 mL | |
| 30 mM | 0.0733 mL | 0.3663 mL | 0.7326 mL | 1.8316 mL | |
| 40 mM | 0.0549 mL | 0.2747 mL | 0.5495 mL | 1.3737 mL | |
| 50 mM | 0.0440 mL | 0.2198 mL | 0.4396 mL | 1.0990 mL | |
| 60 mM | 0.0366 mL | 0.1832 mL | 0.3663 mL | 0.9158 mL | |
| 80 mM | 0.0275 mL | 0.1374 mL | 0.2747 mL | 0.6869 mL | |
| 100 mM | 0.0220 mL | 0.1099 mL | 0.2198 mL | 0.5495 mL |
ZL-Pin13 Related Classifications
HY-143903 Related Classifications
Powered by Bioz