ZL-Pin13
ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells.
For research use only. We do not sell to patients.
- CAS No.: 2883498-73-3
- Formula: C24H23ClN2O3S
- Molecular Weight:454.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
2.8 μM
Compound: ZL-Pin13
|
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 35089030] |
| MDA-MB-468 | IC50 |
1.9 μM
Compound: ZL-Pin13
|
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 35089030] |
Chemical Information
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CAS No. 2883498-73-3
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Molecular Weight 454.97
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Formula C24H23ClN2O3S
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SMILES
O=C(CSC12CCN(CC2)C(CCl)=O)N1CC3=CC=C(O3)C4=CC=CC5=C4C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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