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KPT-6566 

Cat. No.: HY-123847
Handling Instructions

KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity.

For research use only. We do not sell to patients.

KPT-6566 Chemical Structure

KPT-6566 Chemical Structure

CAS No. : 881487-77-0

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Description

KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity[1].

IC50 & Target

IC50: 640 nM (PIN1 PPIase)[1]
Ki: 625.2 nM (PIN1 PPIase)[1]

Molecular Weight

443.54

Formula

C₂₂H₂₁NO₅S₂

CAS No.

881487-77-0

SMILES

O=C(O)CSC(C1=O)=C/C(C2=C1C=CC=C2)=N\S(=O)(C3=CC=C(C(C)(C)C)C=C3)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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KPT-6566
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HY-123847
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