881487-77-0
Chemical Structure
KPT-6566
- CAS No.: 881487-77-0
- Formula:C22H21NO5S2
- Molecular Weight:443.54
IUPAC Name: (E)-2-((4-(((4-(tert-butyl)phenyl)sulfonyl)imino)-1-oxo-1,4-dihydronaphthalen-2-yl)thio)acetic acid
InChIKey: BXWWOKYIKNEEHJ-PTGBLXJZSA-N
SMILES: O=C(O)CSC(C1=O)=C/C(C2=C1C=CC=C2)=N\S(=O)(C3=CC=C(C(C)(C)C)C=C3)=O
Biological Activity: KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 value of 640 nM and a Ki value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KPT-6566 | 98.0% | KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 value of 640 nM and a Ki value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer. | ||||||||||||||||||||
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