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Cat. No.: HY-151627

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11β-HSD1-IN-11

11β-HSD1-IN-11 (Compound c1a) is a competitive 11β-HSD1 inhibitor with IC₅₀s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively.

For research use only. We do not sell to patients.

CAS No.: 859721-81-6
Formula: C₁₅H₁₁F₃O₃S
Molecular Weight:328.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

11β-HSD1-IN-11 Chemical Structure

CAS No.: 859721-81-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

11β-HSD1-IN-11 (Compound c1a) is a competitive 11β-HSD1 inhibitor with IC₅₀s of 0.34 μM and 0.13 μM against rat and human 11β-HSD1, respectively^[1].

IC₅₀ & Target

IC50: 0.13 μM (Rat 11β-HSD1), 0.34 μM (Human 11β-HSD1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>200 μM Compound: 2a	Inhibition of human 11beta-HSD2 expressed in CHO cells Inhibition of human 11beta-HSD2 expressed in CHO cells	[PMID: 17490884]
CHO	IC₅₀	0.187 μM Compound: 2a	Inhibition of human 11beta-HSD1 expressed in CHO cells Inhibition of human 11beta-HSD1 expressed in CHO cells	[PMID: 17490884]
CHO	IC₅₀	190 nM Compound: chart 1, Wyeth	Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISA Inhibition of human 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISA	[PMID: 19053753]

In Vivo

A single dose of the 11β-HSD1 inhibitor Merck 544 reduced the overall abundance of 11β-HSD1-IN-11 (Compound c1a) (15 mg/kg; oral gavage; once) in the rat liver^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 859721-81-6
Molecular Weight 328.31
Formula C₁₅H₁₁F₃O₃S
SMILES

FC(C1=CC=C(C(CS(=O)(C2=CC=CC=C2)=O)=O)C=C1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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