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Cat. No.: HY-137122

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3-Pyridine toxoflavin

3-Pyridine toxoflavin (compound 49) is a PIN1 inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder.

For research use only. We do not sell to patients.

CAS No.: 32502-20-8
Formula: C₁₂H₁₀N₆O₂
Molecular Weight:270.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

3-Pyridine toxoflavin Chemical Structure

CAS No.: 32502-20-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

3-Pyridine toxoflavin (compound 49) is a PIN1 inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	4.3 μM Compound: 4j	Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay	[PMID: 31784197]
HepG2	IC₅₀	1.8 μM Compound: 4j	Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay	[PMID: 31784197]

In Vitro

3-Pyridine toxoflavin shows an average (high-throughput screen) HTS potency of 25 μM and 48% inhibition efficacy for PIN1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 32502-20-8
Molecular Weight 270.25
Formula C₁₂H₁₀N₆O₂
SMILES

O=C(C1=NC(C2=CC=NC=C2)=NN(C)C1=N3)N(C)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. LU, Kun Ping, et al. Methods and compositions for the inhibition of pin1. US20150133442. 2014.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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