PPIase-Parvulin inhibitor
Based on 1 Customer Validation
PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs).
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 64005-90-9
- Formula: C22H18N2O8
- Molecular Weight:438.39
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MEF | IC50 |
1 μM
Compound: 19
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Anticancer activity against mouse MEF cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Anticancer activity against mouse MEF cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
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[PMID: 37438908] |
PPIase-Parvulin Inhibitor can inhibit the proliferation of wild-type MEFs (IC50: ~1 μM), but its effect on Pin1-/- MEFs is not significant[ 1 ].
The inhibitory potency (IC50s) of PPIase-Parvulin Inhibitor against HCT116 and HSC2 cells was 1.2 μM and 0.7 μM[1], respectively.
PPIase-Parvulin Inhibitor (1 μM; 48 h) can reduce the protein levels of cyclins D1 and B1 in HCT116 cells, but has no significant effect on cyclins E and A[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:1 μM
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Incubation Time:24 h, 48 h
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Result:Showed decreased expression of cyclins D1 and B1. In contrast, cyclins E and A were relatively unaffected.
Chemical Information
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CAS No. 64005-90-9
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Appearance Solid
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Molecular Weight 438.39
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Formula C22H18N2O8
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Color Off-white to light yellow
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SMILES
O=C(N(CC(OCC)=O)C1=O)C2=CC=C(C3=C4C=CC1=C23)C(N(CC(OCC)=O)C4=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 0.5 mg/mL (1.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2811 mL | 11.4054 mL | 22.8107 mL | 57.0268 mL |
PPIase-Parvulin inhibitor Related Classifications
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