H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA
Based on 1 Customer Validation
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins.
For research use only. We do not sell to patients.
- Purity : 98.88%
- CAS No.: 202739-41-1
- Formula: C49H59N12O13P
- Molecular Weight:1055.04
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 202739-41-1
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Appearance Solid
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Molecular Weight 1055.04
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Formula C49H59N12O13P
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Color White to off-white
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Sequence
Trp-Phe-{pTyr}-Ser-Pro-Arg-{pNA}
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Sequence Shortening
WF-{pTyr}-SPR-{pNA}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (47.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. M B Yaffe, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12;278(5345):1957-60. [Content Brief]
[2]. Kelly E Duncan, et al. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. J Med Chem. 2011 Jun 9;54(11):3854-65. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9478 mL | 4.7392 mL | 9.4783 mL | 23.6958 mL |
| 5 mM | 0.1896 mL | 0.9478 mL | 1.8957 mL | 4.7392 mL | |
| 10 mM | 0.0948 mL | 0.4739 mL | 0.9478 mL | 2.3696 mL | |
| 15 mM | 0.0632 mL | 0.3159 mL | 0.6319 mL | 1.5797 mL | |
| 20 mM | 0.0474 mL | 0.2370 mL | 0.4739 mL | 1.1848 mL | |
| 25 mM | 0.0379 mL | 0.1896 mL | 0.3791 mL | 0.9478 mL | |
| 30 mM | 0.0316 mL | 0.1580 mL | 0.3159 mL | 0.7899 mL | |
| 40 mM | 0.0237 mL | 0.1185 mL | 0.2370 mL | 0.5924 mL |
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA Related Classifications
HY-P3480 Related Classifications
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