202739-41-1
Chemical Structure
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA
- CAS No.: 202739-41-1
- Formula:C49H59N12O13P
- Molecular Weight:1055.04
IUPAC Name: (R)-2-isopropylpiperazine
InChIKey: VFYGHIVJSUHWET-NLDSVXPCSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](COP(O)(O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O)NC([C@H](CC4=CC=CC=C4)NC([C@@H](N)CC5=CNC6=CC=CC=C56)=O)=O
Biological Activity: H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins[1][2].
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H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA | H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins. | |||||||||||||||||||||
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- [1]. M B Yaffe, et al. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12;278(5345):1957-60. [Content Brief]
- [2]. Kelly E Duncan, et al. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. J Med Chem. 2011 Jun 9;54(11):3854-65. [Content Brief]
Keywords
