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S100P-IN-1 

Cat. No.: HY-146695 Purity: 99.74%
COA Handling Instructions

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC50 of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells.

For research use only. We do not sell to patients.

S100P-IN-1 Chemical Structure

S100P-IN-1 Chemical Structure

CAS No. : 690991-06-1

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5 mg USD 200 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1100 In-stock
100 mg USD 1650 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

S100P-IN-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC50 of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells[1].

IC50 & Target

IC50: 22.7 nM (S100P)[1]
In Vitro

S100P-IN-1 (Compound 4) blocks S100P binding to RAGE in a dose dependent manner[1].
S100P-IN-1 (10 µM, 24 h) shows S100P-specific inhibitory effect on cell invasion, without obvious cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S100P-IN-1 Related Antibodies

Cell Invasion Assay[1]

Cell Line: Human pancreatic cancer cell lines PanC-1 (ATCC- CRL-1469), and BxPC-3 (ATCC-CRL-1687)
Concentration: 10 µM
Incubation Time: 48 h
Result: Significantly inhibited invasion to the lower chamber in BxPC-3 cells, but didn’t inhibit invasion of PanC-1 (lack S100P expression) cells.

Cell Viability Assay[1]

Cell Line: BxPC-3 and Panc-1 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Showed no significant effect on cell metabolic activity and cytotoxicity in either cell line.
Molecular Weight

440.40

Appearance

Solid

Formula

C25H16N2O6
CAS No.
SMILES

O=C(C1=CC(N2C(C3C4C5=CC=CC=C5C(C6=CC=CC=C64)(C3C2=O)[N+]([O-])=O)=O)=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (227.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2707 mL 11.3533 mL 22.7066 mL
5 mM 0.4541 mL 2.2707 mL 4.5413 mL
10 mM 0.2271 mL 1.1353 mL 2.2707 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.68 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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S100P-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

S100P-IN-1690991-06-1OthersPanC-1BxPC-3Anti-metastaticInhibitorinhibitorinhibit

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