PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIN1 is a peptidyl-prolyl isomerase (PPIase) that specifically recognizes the pSer/Thr-Pro motif, catalyzes the cis and trans isomerization of the proline amide bond, changes the conformation of the substrate protein, thereby affecting its function, stability or intracellular localization. PIN1 regulates cell cycle proteins such as cyclin D, cyclin E, and CDC25, thereby regulating the G1-S process and mitotic progression. PIN1 regulates the stability of proteins such as p53 and p73, responds to stress signals such as DNA damage, and thus affects cell cycle arrest or apoptosis. PIN1 regulates the phosphorylation of tau protein, mediating the neurological functions. PIN1 regulates transcription factors such as NF-κB and JUN, mediates immune responses. PIN1 dysfunction could lead to Alzheimer's disease, cancer, asthma, or microbial infection[1][2].
All Product Categories
-
PIN1 Related Products (33)
Related Products (33)
-
Antibodies (2)
- 1
- 2
-
Zingibroside R1
0 ImagesZingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candida albicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection.
-
PPIase-Parvulin inhibitor
0 ImagesPPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 µM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs).
-
PROTAC PIN1 degrader-1
0 ImagesCat. No.: HY-168037CAS No.: 3038591-59-9PROTAC PIN1 degrader-1 is a PIN1-target PROTAC degrader. PROTAC PIN1 degrader-1 TFA can be used for the research of triple-negative breast cancer, pancreatic cancer, and liver cancer.
-
(Rac)-P1D-34
0 Images(Rac)-P1D-34 is a Pin1 PROTAC degrader that recruits cereblon, with a DC50 of 177 nM. (Rac)-P1D-34 induces Pin1 degradation via proteasome- and ubiquitin-like modification-dependent pathways. (Rac)-P1D-34 upregulates ROS and DNA damage, downregulates the UPR pathway, and inhibits leukemia cell proliferation; it also sensitizes drug-resistant acute myeloid leukemia cells to Venetoclax (ABT-199) (HY-15531) by downregulating Mcl-1 levels. (Rac)-P1D-34 can be used in the research of acute myeloid leukemia.
-
PROTAC PIN1 degrader-1 TFA
0 ImagesCat. No.: HY-168037APROTAC PIN1 degrader-1 TFA is a PIN1-target PROTAC degrader. PROTAC PIN1 degrader-1 TFA can be used for the research of triple-negative breast cancer, pancreatic cancer, and liver cancer.
-
BCPA
0 ImagesBCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research.
-
TAB29
0 ImagesCat. No.: HY-128592CAS No.: 2361144-71-8TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC50 of 874 nM, possesses therapeutic potential for human cancers.
-
Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np
0 ImagesCat. No.: HY-187112CAS No.: 202739-37-5
-
PROTAC PIN1 degrader-2
0 ImagesCat. No.: HY-186218CAS No.: 3083422-10-7PROTAC PIN1 degrader-2 is a PROTAC PIN1 degrader. PROTAC PIN1 degrader-2 reduces PIN1-mediated oncogene expression, upregulates PIN1-inhibited tumor suppressor genes, and exerts killing effects on cancer cells. PROTAC PIN1 degrader-2 inhibits tumor growth in breast cancer mouse xenograft models. PROTAC PIN1 degrader-2 can be used for the research of breast cancer.
-
PIN1 ligand-2
0 ImagesCat. No.: HY-171442CAS No.: 2957895-02-0
-
PIN1 degrader-3
0 ImagesCat. No.: HY-179577CAS No.: 3101950-55-1PIN1 degrader-3 is a Pin1 (peptidyl-prolyl isomerase protein) (IC50=4.65 nM) molecular glue degrader. PIN1 degrader-3 bound covalently to Pin1. PIN1 degrader-3-induced Pin1 degradation reduced cell viability. PIN1 degrader-3 can destabilize Pin1 in vitro, causing its degradation in cells. PIN1 degrader-3 can be used for the study of pancreatic cancer.
-
PIN1 degrader-1
0 ImagesCat. No.: HY-164895CAS No.: 3080918-50-6PIN1 degrader-1 is a covalent PIN1 degrader with an IC50 of 21.5 nM. PIN1 degrader-1 induces a decrease in the thermal stability of PIN1, and triggers PIN1 degradation in a concentration- and time-dependent manner across various cancer cells. PIN1 degrader-1 also reduces the viability of pancreatic cancer, breast cancer, prostate cancer and lung cancer cells. PIN1 degrader-1 can be used for research on pancreatic cancer, breast cancer, prostate cancer and non-small cell lung cancer.
-
PIN1-IN-7
0 ImagesCat. No.: HY-184932PIN1-IN-8 is a covalent inhibitor of Pin1, with IC50 values of 4.19 μM and 1.54 μM against purified Pin1 and Pin1 enzymatic activity, respectively. PIN1-IN-7 exerts antiproliferative effects and induces apoptosis by downregulating c-Myc and Cyclin D1. PIN1-IN-7 can be used in the research of triple-negative breast cancer.
-
3-Pyridine toxoflavin
0 ImagesCat. No.: HY-137122CAS No.: 32502-20-83-Pyridine toxoflavin (compound 49) is a PIN1 inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder.
- 1
- 2
