2957895-04-2
Chemical Structure
(Rac)-P1D-34
- CAS No.: 2957895-04-2
- Formula:C40H59ClN6O9S
- Molecular Weight:835.45
InChIKey: LPKVYTQGJNTZKY-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)N2C(C3=CC=C(NCCCCCCCCCCCCNC(CCC(NCC(C)(CN(C4CCS(=O)(C4)=O)C(CCl)=O)C)=O)=O)C=C3C2=O)=O)=O
Biological Activity: (Rac)-P1D-34 is a Pin1 PROTAC degrader that recruits cereblon, with a DC50 of 177 nM. (Rac)-P1D-34 induces Pin1 degradation via proteasome- and ubiquitin-like modification-dependent pathways. (Rac)-P1D-34 upregulates ROS and DNA damage, downregulates the UPR pathway, and inhibits leukemia cell proliferation; it also sensitizes drug-resistant acute myeloid leukemia cells to Venetoclax (ABT-199) (HY-15531) by downregulating Mcl-1 levels. (Rac)-P1D-34 can be used in the research of acute myeloid leukemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(Rac)-P1D-34 | 99.45% | (Rac)-P1D-34 is a Pin1 PROTAC degrader that recruits cereblon, with a DC50 of 177 nM. (Rac)-P1D-34 induces Pin1 degradation via proteasome- and ubiquitin-like modification-dependent pathways. (Rac)-P1D-34 upregulates ROS and DNA damage, downregulates the UPR pathway, and inhibits leukemia cell proliferation; it also sensitizes drug-resistant acute myeloid leukemia cells to Venetoclax (ABT-199) (HY-15531) by downregulating Mcl-1 levels. (Rac)-P1D-34 can be used in the research of acute myeloid leukemia. | ||||||||||||||||||||
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References
- [1]. Shi Y, et al. Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia. Chemical science. 2024 Mar 27;15(13):5027-5035. [Content Brief]
- [2]. Zhou B, et al. Compound for degrading Pin1 protein in targeted ubiquitination, and pharmaceutical composition and application thereof. CN116425733A. China National Intellectual Property Administration. 2023-07-14.
