2. PI3K/Akt/mTOR
  3. PIN1
  4. PROTAC PIN1 degrader-1 TFA

PROTAC PIN1 degrader-1 TFA is a PIN1-target PROTAC degrader. PROTAC PIN1 degrader-1 TFA can be used for the research of triple-negative breast cancer, pancreatic cancer, and liver cancer.
(Pink: PIN1 ligand (HY-168038); Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

PROTAC PIN1 degrader-1 TFA

PROTAC PIN1 degrader-1 TFA Chemical Structure

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PROTAC PIN1 degrader-1 TFA Related Antibodies

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Description

PROTAC PIN1 degrader-1 TFA is a PIN1-target PROTAC degrader. PROTAC PIN1 degrader-1 TFA can be used for the research of triple-negative breast cancer, pancreatic cancer, and liver cancer[1]. (Pink: PIN1 ligand (HY-168038); Blue: Cereblon ligand (HY-14658); Black: linker).

In Vitro

PROTAC PIN1 degrader-1 (compound D4) TFA (24 h) potently and selectively induces on-target degradation of PIN1 protein in MDA-MB-468 cells with a DC50 of 18 nM and maximum degradation of 92.52%[1].
PROTAC PIN1 degrader-1 (96 h) TFA does not exhibit significant antiproliferative activity in MDA-MB-468, PANC-1, or Huh-7 cancer cells, with a GI50 greater than 30 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC PIN1 degrader-1 TFA Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468, PANC-1, and Huh-7 human cancer cells
Concentration: serial concentrations
Incubation Time: 96 h
Result: Exhibited no meaningful antiproliferative activity, with a GI50 > 30 μM in all three tested cancer cell lines.
Molecular Weight

1031.04

Formula

C53H53F3N10O9
SMILES

CC1=CC=CN=C1C2(CC2)C(NC(CC(N=N3)=CN3C(C=C4)=CC=C4C(C=C5)=CC=C5C#N)C(NC(CC6)CCN6CCCCCOC7=CC=CC(C8=O)=C7C(N8C(CC9)C(NC9=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC PIN1 degrader-1 TFA Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC PIN1 degrader-1PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1triple-negative breast cancer cellsPANC-1 cellsCRBN ligandE3 ubiquitin ligase complexpancreatic cancerHuh-7 cellsliver cancerMDA-MB-468 cellstriple-negative breast cancerInhibitorinhibitorinhibit

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