PIN1 degrader-1
PIN1 degrader-1 (Compound 158H9) is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 21.5 nM. PIN1 degrader-1 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation. PIN1 degrader-1 inhibits the cell viability of multi cancer cells, and can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3080918-50-6
- Formula: C30H32Cl2N6O4
- Molecular Weight:611.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 3080918-50-6
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Molecular Weight 611.52
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Formula C30H32Cl2N6O4
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SMILES
NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H]3CCCCN3C([C@H](CC4=CNC5=C4C=CC(Cl)=C5)NC(CCl)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PIN1 degrader-1 Related Classifications
HY-164895 Related Classifications
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