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製品番号: HY-184932

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PIN1-IN-7

PIN1-IN-8 is a covalent inhibitor of Pin1, with IC₅₀ values of 4.19 μM and 1.54 μM against purified Pin1 and Pin1 enzymatic activity, respectively. PIN1-IN-7 exerts antiproliferative effects and induces apoptosis by downregulating c-Myc and Cyclin D1. PIN1-IN-7 can be used in the research of triple-negative breast cancer.

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分子式: C₁₈H₁₉NO₅S₂
分子量:393.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIN1-IN-7 構造式

容量

価格（税別）

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CDK アイソフォーム固有の製品をすべて表示 :

体外実験

PIN1-IN-7 (Compound T7) inhibits the proliferation of MDA-MB-231 and HCT116 cancer cells after 96 h, with IC₅₀ values of 14.35 μM and 13.80 μM, respectively^[1].
PIN1-IN-7 (96-120 h) inhibits the proliferation of breast cancer cell lines, with IC₅₀ values of 14.35 μM and 6.89 μM against MDA-MB-231 and MDA-MB-468, respectively^[1].
PIN1-IN-7 (14 days) potently inhibits the colony-forming ability of MDA-MB-231 and HCT116 cancer cells, with IC₅₀ values of 1.14 μM and 3.36 μM, respectively^[1].
PIN1-IN-7 (2-8 μM; 24-72 h) induces apoptosis and G0/G1 phase arrest in MDA-MB-468 cells, and inhibits cell migration^[1].
PIN1-IN-7 (12-48 h) reduces Pin1 substrates, inhibits oncoproteins such as c-Myc and cyclin D1, and upregulates the cleavage of the apoptotic signaling protein PARP1 in MDA-MB-468 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

MDA-MB-468 cells
Concentration:

2, 4 and 8 μM
Incubation Time:

72 h
Result:

Induced early apoptosis increased from 0.98% to 39.70%.

Cell Cycle Analysis^[1]

Cell Line:

MDA-MB-468 cells
Concentration:

2, 4 and 8 μM
Incubation Time:

48 h
Result:

Induced the cells to shift from the G0/G1 phase by 62.02% to 67.18%.

Cell Migration Assay ^[1]

Cell Line:

MDA-MB-468 cells
Concentration:

2, 4 and 8 μM
Incubation Time:

24 h
Result:

Exhibited dose-dependent inhibition of cell migration.

化学情報

分子量 393.48
分子式 C₁₈H₁₉NO₅S₂
SMILES

O=C(N(C1CS(CC1)(=O)=O)CC2=CC3=C(S2)C=CC=C3)/C=C/C(OC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Tian M, et al. Structure-Based Discovery of (E)- and (Z)- 和 (Z)-4-Oxobut-2-enoate Derivatives as Novel Covalent Pin1 Inhibitors with Antitumor Activity. J Med Chem. 2026 Jul 2.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
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- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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PIN1-IN-7

CDK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

PIN1-IN-7 関連分類

HY-184932 関連分類