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Sulfopin  (Synonyms: PIN1-3)

Cat. No.: HY-139361 Purity: 99.90%
COA Handling Instructions

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors.

For research use only. We do not sell to patients.

Sulfopin Chemical Structure

Sulfopin Chemical Structure

CAS No. : 2451481-08-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 143 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 143 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sulfopin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors[1].

In Vitro

MDA-MB-468 cells show the most pronounced sensitivity to Sulfopin (1, 2.5 μM; 4-8 days)[1].
Sulfopin (2 μM, HEK293 cells; 48 hours) downregulates Myc transcription[1].
Sulfopin (1, 2.5 μM; PATU-8988T cells; 4 days) shows a small but significant reduction in the number of synthesis (S)-phase cells and a corresponding increase of growth 1 (G1)-phase cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Kuramochi, MDA-MB-468, NGP, NBL-S, MDA-MB-468 cells
Concentration: 1, 2.5 μM
Incubation Time: 4,6, 8 days
Result: Showed variation in antiproliferative effects across cancer cell lines Kuramochi, MDA-MB-468, NGP and NBL-S, with the most pronounced sensitivity observed in MDA-MB-468 cells.
In Vivo

Sulfopin (40 mg/kg; p.o.; QD/BID for 7 days) regresses neuroblastoma in mice[1].
Sulfopin (20-40 mg/kg; i.p.; daily for 27 days) inhibits pancreatic cancer progression in mice[1].
Sulfopin (25-100 μM) blocks neuroblastoma in zebrafish[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic Th-MYCN mice[1]
Dosage: 40 mg/kg
Administration: Once a day (QD) or twice a day (BID) for 7 days
Result: Sulfopin-treated QD mice showed a significant average increase in survival of 10 days, while Sulfopin-treated BID mice showed an even more pronounced average increase of 28 days.
Molecular Weight

281.80

Appearance

Solid

Formula

C11H20ClNO3S
CAS No.
SMILES

O=C(N(CC(C)(C)C)C(CC1)CS1(=O)=O)CCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (354.86 mM; Need ultrasonic)

H2O : 4.35 mg/mL (15.44 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5486 mL 17.7431 mL 35.4862 mL
5 mM 0.7097 mL 3.5486 mL 7.0972 mL
10 mM 0.3549 mL 1.7743 mL 3.5486 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.87 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.90%

COA (252 KB) HNMR (254 KB) LCMS (261 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Sulfopin2451481-08-4PIN1-3OthersMDA-MB-468cellstumorsantiproliferativeHEK293neuroblastomapancreaticcancerInhibitorinhibitorinhibit

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