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FEN1-IN-4 

Cat. No.: HY-136485 Purity: 98.23%
Handling Instructions

FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor.

For research use only. We do not sell to patients.

FEN1-IN-4 Chemical Structure

FEN1-IN-4 Chemical Structure

CAS No. : 1995893-58-7

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Description

FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor[1].

IC50 & Target

hFEN1[1]

In Vitro

FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1].

Molecular Weight

232.24

Formula

C₁₂H₁₂N₂O₃

CAS No.

1995893-58-7

SMILES

O=C(N1O)N(CC2CC2)C3=C(C=CC=C3)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (538.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3059 mL 21.5295 mL 43.0589 mL
5 mM 0.8612 mL 4.3059 mL 8.6118 mL
10 mM 0.4306 mL 2.1529 mL 4.3059 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.96 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

FEN1-IN-4OthershumanflapendonucleasehFEN1coloncancercellsglioblastomacolorectalInhibitorinhibitorinhibit

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FEN1-IN-4
Cat. No.:
HY-136485
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