1. Immunology/Inflammation
  2. Cyclic GMP-AMP Synthase
  3. G150

G150 

Cat. No.: HY-128583 Purity: 98.61%
COA Handling Instructions

G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory.

For research use only. We do not sell to patients.

G150 Chemical Structure

G150 Chemical Structure

CAS No. : 2369751-30-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 385 In-stock
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid
1 mg USD 166 In-stock
5 mg USD 350 In-stock
10 mg USD 550 In-stock
25 mg USD 940 In-stock
50 mg USD 1550 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory[1].

IC50 & Target

IC50: 10.2 nM (h-cGAS)[1]

In Vitro

G150 (0.1-100 μM; 1 h) affects IFNB1 and CXCL10 expression in human THP1 cells and primary human macrophages[1].
? G150 (5-10 μM; 1 h) affects dsDNA sensing in THP1 cells and primary human macrophages[1].
? G150 (0.1-100 μM; 1 h) affects the NF-κB pathway activation in THP1-Dual cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Human THP1 cells and primary human macrophages
Concentration: 0.1-100 μM
Incubation Time: 1 hour
Result: Dose-dependently inhibited IFNB1 and interferon-stimulated genes monitoring CXCL10 expression with IC50s of 1.96 and 7.57 μM respectively in human THP1 cells, and inhibited IFNB1 and CXCL10 expression with IC50s of 0.62 and 0.87 μM respectively in primary human macrophages.

RT-PCR[1]

Cell Line: Human THP1 cells and primary human macrophages
Concentration: 5 and 10 μM
Incubation Time: 1 hour
Result: Inhibited dsDNA sensing with a concentration of 10 μM in THP1 cells and with a concentration of 5 μM in primary human macrophages.

RT-PCR[1]

Cell Line: THP1-Dual cells
Concentration: 0.1-100 μM
Incubation Time: 1 hour
Result: Inhibited SEAP activity and luciferase activity with IC50s of 0.90 and 1.79 μM respectively in THP1-Dual cells.
Clinical Trial
Molecular Weight

391.25

Formula

C18H16Cl2N4O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=CC=C(C2=C3C(NC4=C3CN(C(CO)=O)CC4)=C(Cl)C(Cl)=C2)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (319.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5559 mL 12.7796 mL 25.5591 mL
5 mM 0.5112 mL 2.5559 mL 5.1118 mL
10 mM 0.2556 mL 1.2780 mL 2.5559 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.32 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.61%

References
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G150 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
G150
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HY-128583
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