Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np
Ac-Ala-Ala-Ser (PO3H2)-Pro-Arg-NH-Np is a PIN1 substrate that undergoes cis-trans isomerization of the peptidyl-prolyl bond under the catalysis of human PIN1 and yeast Ess1. Ac-Ala-Ala-Ser (PO3H2)-Pro-Arg-NH-Np can be used in breast cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 202739-37-5
- Formula: C28H43N10O12P
- Molecular Weight:742.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Ac-Ala-Ala-Ser (PO3H2)-Pro-Arg-NH-Np (0.3-0.7 mM; time course of cis/trans isomerization) serves as a high-efficiency substrate for purified human Pin1, with a kcat/Km value of 9300 mM-1 s-1; it also acts as a high-efficiency substrate for purified yeast Ess1, with a kcat/Km value of 12000 mM-1 s-1[1].
Ac-Ala-Ala-Ser (PO3H2)-Pro-Arg-NH-Np serves as the optimal-length substrate for purified Pin1 enzyme, while its phosphorylated D-serine analog loses substrate activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 202739-37-5
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Molecular Weight 742.67
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Formula C28H43N10O12P
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SMILES
O=P(O)(OC[C@H](NC([C@@H](NC([C@@H](NC(C)=O)C)=O)C)=O)C(N1[C@H](C(N[C@@H](CCCNC(N)=N)C(NC2=CC=C([N+]([O-])=O)C=C2)=O)=O)CCC1)=O)O
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Sequence
Ac-Ala-Ala-{Ser(PO3H2)}-Pro-{Arg(NH-Np)}
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Sequence Shortening
Ac-AA-{Ser(PO3H2)}-P-{Arg(NH-Np)}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np Related Classifications
HY-187112 Related Classifications
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