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Cat. No.: HY-187112

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Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np

Ac-Ala-Ala-Ser (PO₃H₂)-Pro-Arg-NH-Np is a PIN1 substrate that undergoes cis-trans isomerization of the peptidyl-prolyl bond under the catalysis of human PIN1 and yeast Ess1. Ac-Ala-Ala-Ser (PO₃H₂)-Pro-Arg-NH-Np can be used in breast cancer-related research.

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CAS No.: 202739-37-5
화학식: C₂₈H₄₃N₁₀O₁₂P
분자량:742.67

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np Chemical Structure

CAS No.: 202739-37-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Ac-Ala-Ala-Ser (PO₃H₂)-Pro-Arg-NH-Np (0.3-0.7 mM; time course of cis/trans isomerization) serves as a high-efficiency substrate for purified human Pin1, with a k_cat/K_m value of 9300 mM^-1 s^-1; it also acts as a high-efficiency substrate for purified yeast Ess1, with a k_cat/K_m value of 12000 mM^-1 s^-1^[1].
Ac-Ala-Ala-Ser (PO₃H₂)-Pro-Arg-NH-Np serves as the optimal-length substrate for purified Pin1 enzyme, while its phosphorylated D-serine analog loses substrate activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 202739-37-5
분자량 742.67
화학식 C₂₈H₄₃N₁₀O₁₂P
SMILES

O=P(O)(OC[C@H](NC([C@@H](NC([C@@H](NC(C)=O)C)=O)C)=O)C(N1[C@H](C(N[C@@H](CCCNC(N)=N)C(NC2=CC=C([N+]([O-])=O)C=C2)=O)=O)CCC1)=O)O
Sequence

Ac-Ala-Ala-{Ser(PO3H2)}-Pro-{Arg(NH-Np)}
Sequence Shortening

Ac-AA-{Ser(PO3H2)}-P-{Arg(NH-Np)}
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Substrate-based design of reversible Pin1 inhibitors. Biochemistry. 2002 Oct 01;41(39):11868-77.

[2]. Zhang Y X. Inhibitors Targeting the Enzymatic Activity and Biological Function of Pin1. Mini‑Reviews in Organic Chemistry, 2004, 1(4):359‑366.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Ac-Ala-Ala-Ser(PO3H2)-Pro-Arg-NH-Np Related Classifications

HY-187112 Related Classifications

Bioz

Keywords

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