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yGsy2p-IN-1 

Cat. No.: HY-131062
Handling Instructions

yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 µM and a Ki of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs).

For research use only. We do not sell to patients.

yGsy2p-IN-1 Chemical Structure

yGsy2p-IN-1 Chemical Structure

CAS No. : 2415003-97-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 418 In-stock
Estimated Time of Arrival: December 31
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 µM and a Ki of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs)[1].

IC50 & Target

IC50: 2.75 µM (hGYS1)[1]
Ki: 1.31 µM (wild-type hGYS1)[1]

In Vitro

yGsy2p-IN-1 (compound 23; 0.1, 1, 10, 100, 1000 µM) has IC50s of 7.89 μM and 33.6 μM for yGsy2p-WT and yGsy2p-Y513L[1].
yGsy2p-IN-1 (100 μM) exhibits almost complete inhibition of synthase activity in both HEK293-PTG and Rat-1 cell lysates[1].

Molecular Weight

352.26

Formula

C₁₆H₁₁F₃N₂O₄

CAS No.

2415003-97-1

SMILES

OC1=CC=C(C2=NNC(C(F)(F)F)=C2C3=CC=C(O)C=C3)C(O)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (177.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8388 mL 14.1941 mL 28.3881 mL
5 mM 0.5678 mL 2.8388 mL 5.6776 mL
10 mM 0.2839 mL 1.4194 mL 2.8388 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

yGsy2p-IN-1Othersyeastglycogensynthase2yGsy2phumanhGYS1pyrazolestoragediseasesGSDsInhibitorinhibitorinhibit

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yGsy2p-IN-1
Cat. No.:
HY-131062
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