Search Result
Results for "
pyrazole
" in MedChemExpress (MCE) Product Catalog:
13
Biochemical Assay Reagents
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W002328
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Biochemical Assay Reagents
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Others
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Pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-12564
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Aurora Kinase
Apoptosis
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Cancer
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Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells .
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- HY-76228
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- HY-100689
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PPT
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Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%) .
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- HY-132518S
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- HY-139994
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- HY-W017032
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Biochemical Assay Reagents
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Others
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1H-Pyrazole-1-carboximidamide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-145551
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Others
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Inflammation/Immunology
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Atinvicitinib is a kind of pyrazole compound. Atinvicitinib has the potential for the research of atopic dermatitis (extracted from patent WO2021123094A1) .
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- HY-118810
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- HY-69052
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Biochemical Assay Reagents
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Others
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1-Methyl-1H-pyrazole-4-carboxaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-34603
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Biochemical Assay Reagents
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Others
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1-Methyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-34027
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Ethyl 5-methyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W004978
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Biochemical Assay Reagents
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Others
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1,5-Dimethyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002351
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Biochemical Assay Reagents
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Others
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Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002736
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Biochemical Assay Reagents
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Others
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N,N'-Di-Boc-1H-pyrazole-1-carboximidamide (Compound 1) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-22365
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Biochemical Assay Reagents
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Others
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1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W007997
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3-Amino-4-ethoxycarbonylpyrazole
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Biochemical Assay Reagents
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Others
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Ethyl 3-amino-1H-pyrazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-A0273
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4-Isopropylantipyrine; Isopropylphenazone
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COX
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Inflammation/Immunology
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Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity .
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- HY-145568
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KVD-824
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Ser/Thr Protease
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Cardiovascular Disease
Metabolic Disease
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Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM).
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- HY-127133
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MPP
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Biochemical Assay Reagents
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MPP is a highly selective estrogen receptor alpha (ERα) antagonist. MPP reduces the ratio of p-ERα/ERα .
https://www.ncbi.nlm.nih.gov/pubmed/29799481
Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94.
https://www.ncbi.nlm.nih.gov/pubmed/25893642
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- HY-131062
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Others
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Metabolic Disease
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yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 µM and a Ki of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) .
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- HY-19408
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Pyr10
3 Publications Verification
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TRP Channel
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Others
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Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca 2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca 2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .
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- HY-128546
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- HY-17475
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- HY-10179
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PHA-739358
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Aurora Kinase
Autophagy
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Cancer
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Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively.
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- HY-100040
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4-Ethoxycarbonylpyrazole
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4-Ethoxycarbonylpyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-111108
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Lactate Dehydrogenase
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Cancer
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LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.
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- HY-Y1298
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Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate
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Endogenous Metabolite
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Metabolic Disease
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Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
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- HY-B1137
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Isopropylaminoantipyrine
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Bacterial
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Inflammation/Immunology
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Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .
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- HY-W002461
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Biochemical Assay Reagents
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Others
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3-Phenyl-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002458
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Biochemical Assay Reagents
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Others
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4-Nitro-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-11087
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SD-06
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p38 MAPK
Autophagy
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Inflammation/Immunology
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SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α .
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- HY-120122
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Others
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Cancer
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PK7088 is a pyrazole and a specific peptide. PK7088 supports the reactivation of mutant p53 by converting it to a form exhibiting wild-type properties. PK7088 exhibit anticancer activity in cancer research .
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- HY-150918S
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Isotope-Labeled Compounds
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Others
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3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl- 13C5 is the 13C labeled 3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl[1].
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- HY-B1137S
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Isotope-Labeled Compounds
Bacterial
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Inflammation/Immunology
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Ramifenazone-d7 is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities[1][2].
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- HY-Y1298R
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Acetoacetate methyl ester (Standard); Methyl 3-oxobutanoate (Standard); Methyl acetoacetate (Standard)
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Endogenous Metabolite
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Metabolic Disease
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Methyl acetylacetate (Standard) is the analytical standard of Methyl acetylacetate. This product is intended for research and analytical applications. Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
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- HY-148037
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Proteasome
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Cardiovascular Disease
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Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor, with IC50s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for research of venous thromboembolism .
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- HY-B1557
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Ametazole
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Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity .
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- HY-B1557A
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Ametazole dihydrochloride
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Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity .
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- HY-143296
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SphK
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Cancer
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SphK1-IN-1 (compound 48) is a SphK1 inhibitor with effective antitumor activity. SphK1-IN-1 inhibits SphK1 ATPase with an IC50 value of 4.02 μM. SphK1-IN-1 can be used for the research of cancer .
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- HY-149530
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EGFR
Apoptosis
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Cancer
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EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase .
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- HY-A0060
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NKK 105
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Lipoxygenase
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Cancer
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Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .
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- HY-110218
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PKA
Epigenetic Reader Domain
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Others
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CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion .
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- HY-151618
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Apoptosis
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Cancer
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Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the research of cancer .
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- HY-148481
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Deubiquitinase
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Cancer
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USP7-IN-10 (compound 1) is a potent ubiquitin-specific protease 7 (USP7) inhibitor, with an IC50 of 13.39 nM .
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- HY-124063
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- HY-147751
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Arrestin
Apelin Receptor (APJ)
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Cardiovascular Disease
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APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively .
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- HY-134978
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SHMT
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Others
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(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively . (Rac)-SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-157223
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- HY-146295
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COX
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Inflammation/Immunology
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COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 5.40, 0.01 and 1.78 μM, respectively .
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- HY-146294
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COX
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Inflammation/Immunology
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COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively .
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- HY-147518
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p38 MAPK
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Inflammation/Immunology
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p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research .
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Cat. No. |
Product Name |
Type |
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- HY-W002328
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Biochemical Assay Reagents
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Pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W017032
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Biochemical Assay Reagents
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1H-Pyrazole-1-carboximidamide hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-I0314
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Biochemical Assay Reagents
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1H-Pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-69052
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Biochemical Assay Reagents
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1-Methyl-1H-pyrazole-4-carboxaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-34603
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Biochemical Assay Reagents
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1-Methyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-I0308
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Biochemical Assay Reagents
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1-Methyl-1H-pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W004978
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Biochemical Assay Reagents
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1,5-Dimethyl-1H-pyrazole-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002351
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Biochemical Assay Reagents
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Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002736
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Biochemical Assay Reagents
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N,N'-Di-Boc-1H-pyrazole-1-carboximidamide (Compound 1) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-22365
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Biochemical Assay Reagents
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1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W007997
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3-Amino-4-ethoxycarbonylpyrazole
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Biochemical Assay Reagents
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Ethyl 3-amino-1H-pyrazole-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002461
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Biochemical Assay Reagents
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3-Phenyl-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W002458
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Biochemical Assay Reagents
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4-Nitro-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-132518S
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Pyrazole N-Demethyl Sildenafil-d3 is the deuterium labeled Pyrazole N-Demethyl Sildenafil[1].
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- HY-150918S
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3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl- 13C5 is the 13C labeled 3-(3-Methyl-1H-Prazol-5-yl)Propanoic Acid (MPP) Methyl,pyrazol yl[1].
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- HY-B1137S
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Ramifenazone-d7 is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities[1][2].
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