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Cat. No.: HY-B1557A

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Betazole dihydrochloride

Name: Betazole dihydrochloride
Brand: MedChemExpress
SKU: HY-B1557A
Price: 60.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Ametazole dihydrochloride)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity.

For research use only. We do not sell to patients.

CAS No.: 138-92-1
Formula: C₅H₁₁Cl₂N₃
Molecular Weight:184.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Betazole dihydrochloride Chemical Structure

CAS No.: 138-92-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Biological Activity

Description

IC₅₀ & Target^[1]

H₂ Receptor

All Histamine Receptor Isoforms :

In Vitro

Betazole (Ametazole) dihydrochloride is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole dihydrochloride induces gastric inhibitory polypeptide (GIP) secretion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 138-92-1
Molecular Weight 184.07
Formula C₅H₁₁Cl₂N₃
SMILES

NCCC1=NNC=C1.[H]Cl.[H]Cl
Synonyms

Ametazole dihydrochloride
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Proc Natl Acad Sci U S A

Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia. [Abstract]

2023 Feb 28;120(9):e2207003120. PMID: 36812204

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [Content Brief]

[2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [Content Brief]

[3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Betazole dihydrochloride

1 Cited Publications

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Biological Activity
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- In Vitro
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Publications (1)
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Betazole dihydrochloride

Fomepizole

AS057278

1H-Pyrazole-4-boronic acid pinacol ester

4-Carboxypyrazole

1-Methyl-1H-pyrazole-3-carboxylic acid

4-Hydroxymethylpyrazole

3-Methylpyrazole

Ethyl 1H-pyrazole-4-carboxylate

3,5-Pyrazoledicarboxylic acid

1,3-Dimethylpyrazole

1-Methyl-1H-pyrazol-3-amine

Ethyl 5-methyl-1H-pyrazole-3-carboxylate

Publications Citing Use of MedChemExpress (MCE) Betazole dihydrochloride

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Betazole dihydrochloride

Fomepizole

AS057278

1H-Pyrazole-4-boronic acid pinacol ester

4-Carboxypyrazole

1-Methyl-1H-pyrazole-3-carboxylic acid

4-Hydroxymethylpyrazole

3-Methylpyrazole

Ethyl 1H-pyrazole-4-carboxylate

3,5-Pyrazoledicarboxylic acid

1,3-Dimethylpyrazole

1-Methyl-1H-pyrazol-3-amine

Ethyl 5-methyl-1H-pyrazole-3-carboxylate

Publications Citing Use of MedChemExpress (MCE) Betazole dihydrochloride

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Betazole dihydrochloride Related Classifications

HY-B1557A Related Classifications

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