Betazole
Based on 1 publication(s) in Google Scholar
Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity.
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- Pureza: 96.66%
- No. CAS: 105-20-4
- Fòrmula: C5H9N3
- Peso molecular:111.15
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-W002736
N,N'-Di-Boc-1H-pyrazole-1-carboximidamide -
HY-75637
3-Amino-5-methylpyrazole -
HY-I0312
4-Iodopyrazole -
HY-78243
4-Bromopyrazole -
HY-W002458
4-Nitropyrazole -
HY-W002457
3-Nitropyrazole -
HY-W016754
4-Bromo-3,5-dimethylpyrazole -
HY-W007681
4-Bromo-1H-pyrazol-3-amine -
HY-W249514
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester-d3 -
HY-B1557R
Betazole (Standard)
Publications Citing Use of MedChemExpress (MCE) Betazole
MoreVer todos los productos específicos de isoformas Histamine Receptor
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Actividad biológica
Descripciòn
IC50 & Target
[2]|
H2 Receptor |
In Vitro
Betazole (Ametazole) is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole induces gastric inhibitory polypeptide (GIP) secretion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 105-20-4
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Appearance Oil
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Peso molecular 111.15
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Fòrmula C5H9N3
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Color Colorless to light yellow
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SMILES
NCCC1=NNC=C1
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Synonyms
Ametazole
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia. [Abstract]2023 Feb 28;120(9):e2207003120. PMID: 36812204
Solvente y solubilidad
In Vitro:
DMSO : 175 mg/mL (1574.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 35 mg/mL (314.89 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (18.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (18.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [Content Brief]
[2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [Content Brief]
[3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.9969 mL | 44.9843 mL | 89.9685 mL | 224.9213 mL |
| 5 mM | 1.7994 mL | 8.9969 mL | 17.9937 mL | 44.9843 mL | |
| 10 mM | 0.8997 mL | 4.4984 mL | 8.9969 mL | 22.4921 mL | |
| 15 mM | 0.5998 mL | 2.9990 mL | 5.9979 mL | 14.9948 mL | |
| 20 mM | 0.4498 mL | 2.2492 mL | 4.4984 mL | 11.2461 mL | |
| 25 mM | 0.3599 mL | 1.7994 mL | 3.5987 mL | 8.9969 mL | |
| 30 mM | 0.2999 mL | 1.4995 mL | 2.9990 mL | 7.4974 mL | |
| 40 mM | 0.2249 mL | 1.1246 mL | 2.2492 mL | 5.6230 mL | |
| 50 mM | 0.1799 mL | 0.8997 mL | 1.7994 mL | 4.4984 mL | |
| 60 mM | 0.1499 mL | 0.7497 mL | 1.4995 mL | 3.7487 mL | |
| 80 mM | 0.1125 mL | 0.5623 mL | 1.1246 mL | 2.8115 mL | |
| 100 mM | 0.0900 mL | 0.4498 mL | 0.8997 mL | 2.2492 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Betazole Related Classifications
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