1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Betazole

Betazole (Synonyms: Ametazole)

Cat. No.: HY-B1557 Purity: 96.86%
Handling Instructions

Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity.

For research use only. We do not sell to patients.

Betazole Chemical Structure

Betazole Chemical Structure

CAS No. : 105-20-4

Size Price Stock Quantity
10 mg USD 270 In-stock
Estimated Time of Arrival: December 31
50 mg USD 730 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].

IC50 & Target[2]

H2 Receptor

 

In Vitro

Betazole (Ametazole) is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole induces gastric inhibitory polypeptide (GIP) secretion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

111.15

Formula

C₅H₉N₃

CAS No.

105-20-4

SMILES

NCCC1=NNC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (2249.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.9969 mL 44.9843 mL 89.9685 mL
5 mM 1.7994 mL 8.9969 mL 17.9937 mL
10 mM 0.8997 mL 4.4984 mL 8.9969 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (18.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (18.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (18.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BetazoleAmetazoleHistamine ReceptorhistaloggastricacidsecretionbileductpressuresecretorycapacityInhibitorinhibitorinhibit

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Product Name:
Betazole
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HY-B1557
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