105-20-4
105-20-4
Chemical Structure
Betazole
Synonym(s): Ametazole
- CAS No.: 105-20-4
- Formula:C5H9N3
- Molecular Weight:111.15
IUPAC Name: 2-(1H-pyrazol-3-yl)ethan-1-amine
InChIKey: JXDFEQONERDKSS-UHFFFAOYSA-N
SMILES: NCCC1=NNC=C1
Biological Activity: Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity[1][2][3].
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Betazole | 96.66% | Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity. | ||||||||||||||||||||
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Betazole (Standard) | ≥98% | Betazole (Standard) is the analytical standard of Betazole. This product is intended for research and analytical applications. Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.96
HY-B1557BBetazole hydrochloride -
Similarity Score 0.93
HY-B1557ABetazole dihydrochloride -
Similarity Score 0.77
HY-B1204Histamine -
Similarity Score 0.73
HY-B0722Histamine dihydrochloride -
Similarity Score 0.73
HY-660543-Methylpyrazole -
Similarity Score 0.72
HY-1075652-Pyridylethylamine hydrochloride -
Similarity Score 0.72
HY-W5807214-Methylhistamine -
Similarity Score 0.70
HY-W002328Pyrazole-3-carboxylic acid -
Similarity Score 0.70
HY-W580721A4-Methylhistamine hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [Content Brief]
- [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [Content Brief]
- [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. [Content Brief]
